MGH Neurology

12/22/2025

Recently, our Neurodegeneration Clinical Research Fellow, Dr. Pinar Uysal, presented an overview on the current state of ALS. Her discussion included updates on ALS diagnosis, treatment, and policy.

Check out the presentation recording here: https://www.vumedi.com/video/als-2025-year-in-review/ImFscy0yMDI1LXllYXItaW4tcmV2aWV3Ig:1vVtI5:UCZ2jCuePgWcvbkhrEgtLXK4iJTuG154ePoaqW-aVuA/

A video from S. Pinar Uysal, posted on Dec 12, 2025.

12/17/2025

The application portal is now open for the 2026 ALS Scholars in Therapeutics!

Apply to this 2-year program to:
▪️Gain training and experience in therapy development for ALS at your home institution
▪️Benefit from mentorship by world renowned scientists and clinicians
▪️Participate in a monthly industry lecture series featuring pharmaceutical industry experts and key opinion leaders

Learn more and apply: https://www.massgeneral.org/neurology/als/research/healey-scholars-program

The ALS Scholars in Therapeutics program engages clinician-scientists and post-doctoral fellows, in their home institution, embarking on their career path to contribute their talents in the ALS field.

12/15/2025

Please join us on Thursday, December 18th, at 5:00 pm ET for a brief presentation and Q&A session on the HEALEY ALS Platform Trial. This week, Dr. Sabrina Paganoni of Mass General Hospital will provide an overview of how new regimens are selected and added to the trial.

Register: https://mgb-org.zoom.us/webinar/register/WN_JW9rQBhTRFW5uoUIDtJguw #/registration



Northeast ALS Consortium (NEALS) ALS ONE I AM ALS EverythingALS Les Turner ALS Foundation Muscular Dystrophy Association ALS TDI The ALS Association

12/09/2025

12/08/2025

The Healey & AMG Center for ALS is pleased to announce that Frank Bradke, PhD, a neuroscientist at the German Center for Neurodegenerative Diseases (DZNE), was awarded the 5th annual Drs. Ayeez and Shelena Lalji & Family ALS Endowed Award for Innovative Healing.

This prize is possible through the generosity of Drs. Ayeez and Shelena Lalji. Drs. Shelena Lalji and Merit Cudkowicz presented the prize to Dr. Bradke at the MND Association International Symposium on ALS/MND.

Read the announcement here: https://www.massgeneral.org/neurology/als/news/fifth-annual-lalji-endowed-award-for-innovative-healing-announced

12/08/2025

The Healey & AMG Center for ALS is pleased to announce that Drs. Rosa Rademakers, Aaron Gitler, Bryan Traynor, and Nancy Bonini were awarded the 7th Annual Sean M. Healey International Prize for Innovation in ALS.

Dr. Merit Cudkowicz presented the prize at the MND Association International Symposium on ALS/MND.

Read the announcement here: https://www.massgeneral.org/neurology/als/news/seventh-annual-sean-m-healey-international-prize-for-innovation-in-als-awarded

The Sean M. Healey & AMG Center for ALS is pleased to announce that the ALS Residence Initiative (ALSRI) was awarded the 2025 Gupta Family Endowed Prize for Innovation in ALS Care. Merit Cudkowicz, MD, MSC, Director of the Healey & AMG Center for ALS, presented the prize to Steve Saling, CEO of ALSR...

12/08/2025

👀 Next week is an all new episode in our Expert Talk Series, featuring Dr. Suma Babu, Co-Director - Neurological Research Institute, Massachusetts General Brigham and Associate Professor of Neurology at Harvard Medical School.

"Healey ALS MyMatch Overview & Updates"
📆 Wednesday, December 10, 2025
⌚ 4 pm PST | 5 pm MST | 6 pm CST | 7 pm EST
📍 register for the zoom event at https://www.everythingals.org/events

We hope you will join us! Please like, comment, and share this post to help spread the word.

12/08/2025

Please join us on Thursday, December 11th, at 5:00 pm ET for a brief presentation and Q&A session on Expanded Access Protocols (EAPs). This week, we are featuring Nicole Johnson and Kate Nycz, who will share their insights on EAPs.

Register: https://mgb-org.zoom.us/webinar/register/WN_JW9rQBhTRFW5uoUIDtJguw #/registration



Northeast ALS Consortium (NEALS) ALS ONE I AM ALS EverythingALS Les Turner ALS Foundation Muscular Dystrophy Association ALS TDI The ALS Association

12/06/2025

It's the 2nd day of the International Symposium on ALS/MND and we have several presenters from the Healey & AMG Center for ALS sharing their work today!

Find the full schedule here: https://symposium.mndassociation.org/

MND Association

Check out below who will be presenting from the Healey & AMG Center for ALS on December 6th, the second day of the MND Association International Symposium on ALS/MND.

▪️8:30am PT: Sabrina Paganoni, Co-Chair for the session on Primary Lateral Sclerosis
▪️11:00am PT: Aaron Held, “AP21A and the autophagy pathway modify TDP-43 toxicity”
▪️12:10pm PT: Alex Sherman, “The International ALS/MND Natural History Consortium: Coordination, data quality, compliance, sustainability and sharing”
▪️3:15pm PT: Laura König, “TYK2 mediates neuroinflammation in brains with cytoplasmic dsRNA co-inciding with TDP-43 pathology: A common therapeutic approach for neurodegenerative diseases.”
▪️4:00pm PT: Suma Babu, Co-Chair for the session "Improving Clinical Decision Making: Research, Policy, and Practice"

Find more details about the conference here: https://symposium.mndassociation.org

12/05/2025

Today, December 5th, is the start of the International Symposium on ALS/MND. Check out who will be presenting today from the Healey & AMG Center for ALS.

Learn more about the symposium here: https://symposium.mndassociation.org/

MND Association

The MND Association International Symposium on ALS/MND begins on Friday, December 5th. We have several members from the Healey & AMG Center presenting at the meeting. Below is the schedule for Friday, the first day.

▪️10:30am PT: Merit Cudkowicz, “Modelling and treating ALS with stem cells: Introduction - Opportunities and challenges”
▪️2:00pm PT: James Berry, Co-Chair for the session, "Clinical Trials and Trial Design."
▪️2:00pm PT: Suma Babu, “DNL343 in ALS: Results from the double-blind placebo-controlled, randomized HEALEY ALS Platform Trial”
▪️2:30pm PT: Adel Boudi, “Characterization and functional evaluation of RNA-driven gene fusions in ALS”
▪️2:45pm PT: Merit Cudkowicz, “From PARADIGM to PARAGON: Advancing PrimeC for ALS through Phase 2 clinical and biomarker insights into a global Phase 3 trial”
▪️5:00pm PT: Taravat Yazdanian, “ALS cervical cord MRI metanalysis shows flattening of the cervical enlargement region”

Learn more about the symposium here: https://symposium.mndassociation.org

12/03/2025

Taravat Yazdanian, a postdoc at the Healey & AMG Center for ALS, will present at the MND Association International Symposium on ALS/MND on December 5th, 5:00pm PT. She will discuss how cervical spinal cord quantitative MRI (qMRI) could be a potential biomarker in ALS.

Read the paper here: https://www.sciencedirect.com/science/article/pii/S2213158225001020