04/15/2026
A Note of Caution: Evaluating ONE-DAY TMS for Depression
Transcranial Magnetic Stimulation (TMS)
Optimizing your mental health is a journey often paved with new technologies and promising protocols. One such advertised method, Optimized, Neuroplasticity-Enhanced techniques in Depression (ONE-DAY TMS), has garnered attention for its compressed timeline and combined approach. However, the Clinical Transcranial Magnetic Stimulation Society (CTMSS), dedicated to evidence-based practice, has recently issued a statement advising caution regarding current claims about its efficacy.
What is ONE-DAY TMS?
ONE-DAY is a specific accelerated Transcranial Magnetic Stimulation (TMS) protocol. It involves a single-day treatment regimen consisting of twenty sessions of 600-pulses intermittent theta burst stimulation. In addition to the stimulation, patients are administered specific oral medications—125 mg of d-cycloserine and 20 mg of lisdexamphetamine—in the morning prior to the treatment sessions.
While single-day and medication-assisted TMS protocols hold significant potential for establishing clinical efficacy in the future, it is crucial to understand the state of the evidence right now.