02/12/2026
Interesting correlation
Strong legs are linked to higher cognitive function, increased gray matter and larger brain volume because they are the body’s largest muscles and act as a powerful engine for cardiovascular health and chemical signaling to the brain. Training them releases myokines (signaling proteins) that boost brain-derived neurotrophic factor (BDNF), enhancing neuroplasticity, while improving blood flow and reducing inflammation that causes brain aging.
To elaborate:
📑Chemical Signaling (Myokines): Activating large leg muscles releases “hormone-like” myokines into the blood, which cross the blood-brain barrier to support memory and neuronal health.
📑Increased Blood Flow: Stronger legs demand more oxygen, improving circulation, which floods the brain with nutrients and oxygen, fostering a healthier environment.
📑Neurogenesis & Reduced Atrophy: The biochemical released (such as BDNF) spark the growth of new neurons, particularly in the hippocampus, directly countering age-related brain shrinkage.
📑Biomarker for Overall Health: Leg strength is a reliable, strong predictor of cognitive aging, sometimes even more indicative than overall fitness, as it reflects a high level of consistent physical activity.
Research indicates that even in identical twins, the twin with higher leg strength showed significantly better cognitive function and more gray matter, with a 40-watt increase in leg power linked to improved brain performance equivalent to being 3.3 years younger. Maintaining strong legs through exercises and strength training effectively protects against brain atrophy.
PMID: 26551663