NEUROmergence

10/10/2025

🌿 𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗥𝗲𝘃𝗲𝗮𝗹𝘀 𝗥𝘂𝘁𝗶𝗻’𝘀 𝗥𝗲𝗺𝗮𝗿𝗸𝗮𝗯𝗹𝗲 𝗔𝗻𝘁𝗶 𝗔𝗴𝗶𝗻𝗴 𝗮𝗻𝗱 𝗛𝗲𝗮𝗹𝗶𝗻𝗴 𝗣𝗼𝘄𝗲𝗿 🌿

A quiet revolution is unfolding in longevity science, and it centers on a natural plant compound called 𝗿𝘂𝘁𝗶𝗻. Found in buckwheat, apples, citrus, and green tea, rutin is a glycoside of quercetin that combines antioxidant strength with a rare natural sugar called 𝗿𝘂𝘁𝗶𝗻𝗼𝘀𝗲, helping it reach deeper into the cells where inflammation and oxidative stress begin.

Recent research is revealing that rutin may do far more than anyone expected:

✨ 𝗥𝗲𝘀𝘁𝗼𝗿𝗲𝘀 𝗦𝗸𝗶𝗻 𝗮𝗻𝗱 𝗖𝗼𝗹𝗹𝗮𝗴𝗲𝗻
A clinical study found that participants who applied a rutin cream for four weeks showed improved skin elasticity and visibly fewer wrinkles, especially around the eyes. In lab tests, rutin increased COL1A1 (collagen production) and reduced MMP1 (collagen breakdown), helping protect the skin’s structure and slow visible aging. [1]

🧬 𝗧𝗮𝗿𝗴𝗲𝘁𝘀 “𝗭𝗼𝗺𝗯𝗶𝗲 𝗖𝗲𝗹𝗹𝘀” 𝗟𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗔𝗴𝗶𝗻𝗴
A 2024 study in Aging Cell discovered that rutin acts as a senomorphic agent, meaning it helps calm harmful signals from senescent or “zombie” cells that drive chronic inflammation. In aged mice, rutin reduced systemic inflammation and improved physical performance, showing real potential as a longevity compound. [2]

⚡️ 𝗣𝗿𝗼𝘁𝗲𝗰𝘁𝘀 𝗔𝗴𝗮𝗶𝗻𝘀𝘁 𝗖𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗦𝘁𝗿𝗲𝘀𝘀 𝗮𝗻𝗱 𝗖𝗮𝗻𝗰𝗲𝗿 𝗣𝗮𝘁𝗵𝘄𝗮𝘆𝘀
Rutin inhibits c Met kinase, an enzyme also targeted by advanced senotherapeutic drugs like Dasatinib. This link suggests rutin could help weaken the defenses of aging or precancerous cells, aligning it with cutting edge longevity science. [3][4]

🏃‍♀️ 𝗦𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝗟𝗶𝗳𝗲𝘀𝗽𝗮𝗻 𝗮𝗻𝗱 𝗩𝗶𝘁𝗮𝗹𝗶𝘁𝘆
In both worms and mice, rutin extended lifespan, improved movement, and lowered oxidative stress markers in the brain. These findings show measurable rejuvenation at the cellular level. [5]

❤️ 𝗘𝗻𝗵𝗮𝗻𝗰𝗲𝘀 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗮𝗻𝗱 𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗛𝗲𝗮𝗹𝘁𝗵
Rutin supplementation improved blood sugar control, lowered blood pressure, and enhanced mitochondrial and antioxidant activity in aging models. [6]

🩸 𝗣𝗿𝗲𝘃𝗲𝗻𝘁𝘀 𝗠𝗶𝗰𝗿𝗼𝗰𝗹𝗼𝘁𝘀 𝗮𝗻𝗱 𝗦𝘂𝗽𝗽𝗼𝗿𝘁𝘀 𝗟𝗼𝗻𝗴 𝗖𝗢𝗩𝗜𝗗 𝗥𝗲𝗰𝗼𝘃𝗲𝗿𝘆
A major study found that rutin can directly inhibit thrombin, slowing clot formation and protecting microcirculation. This may help reduce the hidden microclots that appear with aging and long COVID, where blocked capillaries limit oxygen to the brain and muscles. [7][10][11][12]

🦠 𝗕𝗹𝗼𝗰𝗸𝘀 𝗖𝗢𝗩𝗜𝗗 𝗣𝗿𝗼𝘁𝗲𝗶𝗻𝘀 𝗶𝗻 𝗖𝗼𝗺𝗽𝘂𝘁𝗲𝗿 𝗠𝗼𝗱𝗲𝗹𝘀
A 2021 study revealed that rutin can bind tightly to several key viral proteins of COVID 19, blocking their ability to replicate and infect cells. Because it is already a safe compound found in food, researchers believe it may hold promise for future therapeutic use. [13]

🌱 𝗔 𝗡𝗮𝘁𝘂𝗿𝗮𝗹 𝗔𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝘁𝗼 𝗟𝗼𝗻𝗴𝗲𝘃𝗶𝘁𝘆
By supporting skin, circulation, brain, and metabolism, rutin stands out as a plant derived molecule that works across multiple systems of the body. It reduces oxidative stress, protects blood vessels, and improves resilience against aging at every level. [14]

📚 References
[1] Choi SJ et al. Int J Mol Med. 2016.
[2] Liu H et al. Aging Cell. 2024.
[3] Elsayed HE et al. Nutr Cancer. 2017.
[4] Sen B et al. Clin Cancer Res. 2011.
[5] Xinghua L et al. Dokl Biochem Biophys. 2023.
[6] Li T et al. Food Funct. 2016.
[7] Choi JH et al. J Biosci Bioeng. 2015.
[10–12] Pretorius E et al.; Kell D B et al.; Ducharme J., Time Magazine 2022.
[13] Rahman F et al. J Tradit Complement Med. 2021.
[14] Al Dhabi NA et al. EXCLI J. 2015.

For the full article and to purchase high-grade, super-critical rutin, please visit:
https://www.mdslabs.shop/product/mds-labs-full-spectrum-rutinocide-500mg/

🔬 These statements have not been evaluated by the Food and Drug Administration. Rutin is not intended to diagnose, treat, cure, or prevent any disease.

Rutin is a bioflavonoid found in plants like buckwheat, apples, citrus fruits, and green tea. It is best known for its strong antioxidant and anti-inflammatory effects, and is also thought to have antiprotozoal, antibacterial, and aintiviral properties. Chemically, rutin is a glycoside, which means....

10/08/2025

I have spent a lot of time comparing what is on the market with what the science actually says. Here is my plain language take for anyone curious about senolytics and what really matters, in the context of natural senotherapeutic formulas.

𝐐𝐮𝐚𝐥𝐢𝐚 𝐒𝐞𝐧𝐨𝐥𝐲𝐭𝐢𝐜
They highlight a small brand run double blind study that relies on self reported questionnaires from 31 individuals, rather than objective biomarkers. The page leans heavily on influencer and celebrity endorsements who admit to owning shares of the business. It also contains soy which many people choose to avoid. The formulation does not explain pathway targeting or why specific doses were chosen relative to senescent cell biology. A total shot in the dark.

𝐑𝐞𝐧𝐮𝐞 𝐁𝐲 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐒𝐞𝐧𝐨𝐥𝐲𝐭𝐢𝐪𝐮𝐞
Liposomal delivery is the selling point here. Unfortunately, we have zero clinical data on the effectiveness of these ingredients in liposomal form. And of course, another drawback is minimal pathway mapping. It lists actives like fisetin quercetin spermidine but gives little rationale for kinase or SASP targets that would mirror benefits of a studied senotherapeutic protococ like D+Q. Another shot in the dark driven by marketing hype.

𝐋𝐢𝐟𝐞 𝐄𝐱𝐭𝐞𝐧𝐬𝐢𝐨𝐧 𝐒𝐞𝐧𝐨𝐥𝐲𝐭𝐢𝐜 𝐀𝐜𝐭𝐢𝐯𝐚𝐭𝐨𝐫
While I love what this company has offered over the years, this one is still light on demonstrating senescence in humans, and does not present a dasatinib adjacent pathway rationale. Think senolytic themed rather than pathway driven.

𝐄𝐥𝐲𝐬𝐢𝐮𝐦 𝐒𝐞𝐧𝐨𝐥𝐲𝐭𝐢𝐜 𝐂𝐨𝐦𝐩𝐥𝐞𝐱
Uses a proprietary blend. The site does not disclose per ingredient amounts which makes it impossible to judge dosing against the literature. Without amounts you cannot independently evaluate or replicate, this is a big red flag in my book.

𝐖𝐡𝐲 𝐍𝐄𝐔𝐑𝐎𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐞?
It is a natural Dasatinib mimietic with therapeutic levels of quercetin to align it to the D+Q protocol, further potentiated by pterostilbene, and includes spermidine, berberine, rutin, ku shen extract for lupeol and oxymatrine, fisetin, and sennocide B. The data provided by MDS Labs links to studies for each ingredient and lays out a pathway table that overlaps key tyrosine kinase and SASP pathways aligned to dasatinib/imatinib. There is also bench level Western blot work that compared the stack to dasatinib. It is not as potent as a drug which is expected, yet it shows inhibition in many of the same neighborhoods. It is soy free and designed for intermittent hit-and-run dosing rather than daily forever.

𝐁𝐢𝐠 𝐩𝐢𝐜𝐭𝐮𝐫𝐞
A lot of companies lean on celebrity marketing and vague claims because most people do not have time to dig through dozens of papers. I prefer to develop products that actually show why each ingredient is there and how the dose relates to the literature. On that score, is simply more transparent and more aligned with a D+Q style approach than any of the other options above.

Broad-spectrum senolytic and senomorphic support formula Includes compounds targeting same anti-aging pathways as D+Q senolytic* Supports cognitive function and long-term neuroprotection* Promotes clearer thinking and sharper memory recall* Boosts youthful energy and daily vitality* Encourages grace...

09/06/2025

Cellular Senescence & Clarity

One of the more under-appreciated aspects of senescent cell accumulation is how it impacts mental clarity. Chronic low-grade inflammation and SASP factors don’t just affect joints and skin — they influence cognition.

NEUROmergence® was built around that connection. By combining eight known senolytic and senomorphic compounds formulated to target a wide range of senescence associated pathways, it addresses the cellular environment that contributes to brain fog and slowed processing.

For those of us who follow the literature, this isn’t about a quick boost — it’s about supporting long-term resilience at the cellular level.

https://www.mdslabs.shop/product/neuromergence/

09/01/2025

🚀 The real breakthroughs in anti aging are not just the discoveries themselves… they are the moment those discoveries become 𝗮𝗰𝗰𝗲𝘀𝘀𝗶𝗯𝗹𝗲 𝘁𝗼 𝗲𝘃𝗲𝗿𝘆𝗼𝗻𝗲.

For decades unique 𝗽𝗵𝘆𝘁𝗼𝗰𝗵𝗲𝗺𝗶𝗰𝗮𝗹𝘀 and advanced extracts required specialized access or remained buried in research. What is different today is the ease of availability, including accessing compounds in their most effective forms, 𝗽𝗿𝗼𝗽𝗲𝗿𝗹𝘆 𝗲𝘅𝘁𝗿𝗮𝗰𝘁𝗲𝗱 𝘄𝗶𝘁𝗵 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝘀𝗼𝗹𝘃𝗲𝗻𝘁 𝘀𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 to maximize purity and function.

That is the true functional breakthrough in anti aging, not just knowing these compounds exist but having everyday access to them.

𝗠𝗗𝗦 𝗟𝗮𝗯𝘀®, 𝗮 𝗥𝗲𝘃𝗲𝗻𝘁𝗲𝗸 𝗯𝗿𝗮𝗻𝗱, was created to bridge advanced longevity science with real world access. From classical formulations like 𝗕𝘂𝘀𝗵𝗲𝗻 𝗬𝗶𝘇𝗶 to modern natural senolytic blends like 𝗡𝗘𝗨𝗥𝗢𝗺𝗲𝗿𝗴𝗲𝗻𝗰𝗲®, our focus is taking research out of the lab and putting it in your hands.

And now with our partnership on 𝗔𝗺𝗮𝘇𝗼𝗻, these innovations are easier to access than ever, a major step forward for the field and for the future of healthy aging. 🌿🧬✨

What unique compounds or formulations would you like to see us come out with next?

👉 Explore NEUROmergence® and more at
www.mdslabs.shop

American Academy of Anti-Aging Medicine (A4M) The American Academy of Anti-Aging Medicine (A4M) Conferences and Exhibits Anti Aging Biohacking, Longevity, CRISPR, Supplements, Life Extension, Wim Hof Senolytic / Senomorphic Research for Longevity / Anti-aging Senescence: the Issues of Aging Wisdom of Traditional Chinese Medicine

Next Generation Senolytic Support Supplement Senolytics are one of the most exciting frontiers in anti aging research. Over time, senescent cells, often called zombie cells, can accumulate and interfere with normal cellular processes. Clearing these cells has become a major focus of longevity sci...