11/05/2025
a new study shows that there seems to be a link between IBS and mast cells. People with IBS didn't have more mast cells, but mast cells were closer to nerve fibers--so they experienced more pain--and there may something about the spacial arrangement of the mast cells, too. Fascinating stuff!
3D imaging of nerve fibers and mast cells double-labeled with antibodies against Substance P (SP, red) and tryptase (green) on CLARITY-cleared human sigmoid colonic mucosal biopsies from an IBS patie...