01/20/2026
VITAMIN D Does NOT Work WITHOUT MAGNESIUM and VITAMIN K2
If you’re taking vitamin D3 without magnesium and vitamin K2 you're not getting the full benefits and in some cases you could even be increasing risk.
Here’s how the system actually works:
1. Vitamin D3 — Calcium Absorption
Vitamin D3 helps your body absorb calcium from food and supplements.
Without enough D3, calcium absorption is poor.
2. Vitamin K2 — Calcium Direction
Vitamin K2 tells calcium where to go:
✔ Into bones and teeth
❌ Not into arteries or soft tissues
Without K2, absorbed calcium can accumulate in blood vessels, contributing to arterial calcification.
3. Magnesium — Vitamin D Activation
Magnesium is required to activate vitamin D.
It converts vitamin D into the active hormone 1,25-dihydroxycholecalciferol (calcitriol).
Around ~50% of people are magnesium deficient, which can silently block vitamin D from working.
Why This Matters
Taking vitamin D alone can:
- Increase calcium absorption without proper regulation (arterial calcifications)
- Stress magnesium stores
- Reduce the effectiveness of vitamin D over time
The Takeaway
Vitamin D + K2 + Magnesium = a functional system
Together, they support:
- Strong bones and teeth
- Healthy arteries
- Better sleep and stress resilience
- Proper calcium metabolism
- Overall metabolic and cardiovascular health
If you want to see the magnesium and Vitamin D3/K2 that I take create an account here https://us.fullscript.com/protocols/ddinicolantonio-general-health
