12/16/2025
Your peptides aren’t broken. Your expectations might be a little rushed.
Peptides don’t work like a one-and-done injection — they’re cellular messengers. They need time to accumulate, regulate receptors, and actually shift physiology. Especially in lighter skin tones (Fitzpatrick I–II), where inflammatory response and temporary fluid shifts can feel more noticeable early on.
GLPs:
Some patients feel anti-inflammatory benefits quickly. Others hold first, then release. Both are normal biology.
Tesamorelin:
Temporary water retention ≠ failure. This phase can take ~6 weeks to settle before visible body-composition changes show up — particularly in leaner or lighter-skin patients.
Bottom line:
This is medicine, not magic. Consistency > impatience. Stay on protocol and let your body catch up.
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MJ. Gandon RN, MSN, FNPgandon .medical