XRpro Sciences, Inc.

08/28/2015

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Icagen offers industry-leading scientific expertise and comprehensive services for ion channel and...

08/27/2015

A recent study published in the 'Proceedings of the National Academy of Sciences' revealed how nanochannels select potassium ions. Find out more: http://bit.ly/1PTw3u6

08/26/2015

A new study published by Nature Neuroscience found ion channel blockers may prove to be useful in cancer therapy. Learn more: http://bit.ly/1K2HSPK

Drugs called ion channel blockers, which are commonly used to treat cardiac, neurological, and psychiatric disorders, might prove useful in cancer therapy, according to research findings in fruit flies and mice by UC San Francisco scientists ...

08/26/2015

Please note: we will be providing news and updates on our brand new Icagen Facebook profile: http://on.fb.me/1JW65Hx

Icagen offers industry-leading scientific expertise and comprehensive services for ion channel and...

08/25/2015

A recent study by the Virginia Commonwealth University and University of Richmond explores one key difference between human and sponge ion channels that researchers now believe developed around the same time the first animals evolved: http://bit.ly/1PQhkA5

08/13/2015

Icagen to offer pharmaceutical and biotechnology companies expert ion channel & transporter services: http://bit.ly/1IRcm0A

CAMBRIDGE, Mass., and DURHAM, N.C., July 2, 2015 /PRNewswire/ -- XRpro Sciences, Inc. today announced its ...

07/27/2015

Icagen will offer industry‐leading scientific expertise and comprehensive access to technologies for ion channel and transporter drug discovery and development. Click to learn more: http://bit.ly/1JD24BQ

07/24/2015

Researchers from Northwestern Medicine report findings in PNAS to understand how a mutation in a channel activator protein, STIM1, prevents calcium release-activated channels (CRAC) from opening, resulting in a lack of activation of T-cells and other immune cells. Specifically, they discovered that the structural alteration caused by the mutation prevents STIM1 from binding to the channel and activating it. http://bit.ly/1JD1eFb

Patients with mutations in specialized calcium ion channels called calcium release-activated channels (CRAC) suffer from a severe immunodeficiency syndrome.

06/25/2015

During this year's Ion Channel Retreat, XRpro's Dr. Nathan Zahler will give a talk highlighting proof of concept data for SLC transporters including new data on zinc transporters. For more information regarding the 2015 Ion Channel Retreat please visit their website. http://bit.ly/1JYa8R7

July 7th – 9th, 2015 | Vancouver BC, Canada. Location: Hyatt Regency Vancouver 655 Burrard Street, Vancouver, British Columbia, Canada, V6C 2R7.

06/23/2015

Mutations in the Piezo1 gene, a mechanosensitive ion channel, have been linked to the blood disease, xerocytosis, that leads to hemolytic anemia. A pair of recent papers have reported the discovery of a synthetic small molecule, Yoda 1, that can activate Piezo 1 in the absence of mechanical stimulation, which in turn caused red cell shrinking via secondary activation of other ion channels. http://bit.ly/1JYyU3J

Researchers have discovered a synthetic small molecule that activates a mechanosensitive ion channel involved in a blood disorder.

06/19/2015

Researchers investigated the role of miR-224 as a regulator of SLC4A4 and CFTR, the key buffering ion transporters in modulating enamel mineralization. Overexpression of miR-224 down-regulated SLC4A4 and CFTR expression via binding to 3’ UTR of SLC4A4 and CFTR mRNA, thereby inhibiting protein translation. http://bit.ly/1G48WqH

ABSTRACT Enamel mineralization is accompanied by releasing protons into the extracellular matrix, which is buffered to regulate pH value in local microenvironment.

06/19/2015

This recent review discusses the distinct role of voltage-gated ion channels (VGIC) in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation. Although VGIC are well known for controlling rapid bioelectrical signaling, studies have demonstrated that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation, all functions critical for cancer cell proliferation. http://bit.ly/1JYtkhv

Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions.