01/19/2026
When someone experiences a stroke, doctors must quickly restore blood flow to the brain to prevent death. However, this sudden return of circulation can also set off a harmful cascade that damages brain cells, drives inflammation, and raises the risk of lasting disability.
Researchers at Northwestern University have now created an injectable regenerative nanomaterial designed to protect the brain during this critical period after blood flow is restored.
In a new preclinical study, the scientists tested a single intravenous dose given immediately following reperfusion in a mouse model of ischemic stroke, the most common form of the condition. The therapy was able to cross the blood-brain barrier, a hurdle that prevents many treatments from reaching brain tissue, and promote repair. Mice that received the treatment showed significantly less brain damage, with no evidence of side effects or toxicity in major organs.
The results, published in the journal Neurotherapeutics, indicate that this approach could eventually work alongside existing stroke therapies by reducing secondary injury and aiding recovery.
New nanomaterial passes the blood-brain barrier to reduce damaging inflammation after the most common form of stroke. When someone experiences a stroke, doctors must quickly restore blood flow to the brain to prevent death. However, this sudden return of circulation can also set off a harmful casca