02/13/2026
๐ด ๐๐ง๐ญ๐๐ซ๐ฅ๐๐ฎ๐ค๐ข๐ง-๐ ๐๐๐๐๐ฉ๐ญ๐จ๐ซ ๐๐ง๐ญ๐๐ ๐จ๐ง๐ข๐ฌ๐ญ ๐๐ซ๐จ๐ญ๐๐ข๐ง - ๐๐๐๐ ๐
Joint inflammation and osteoarthritis are common causes of pain and decreased performance in horses. One of the advanced therapies we use at Signature Equine Hospital is IRAP, or Interleukin-1 Receptor Antagonist Protein therapy. A cutting-edge, biologic treatment that harnesses your horseโs own immune system to combat joint inflammation.
๐ ๐๐ก๐๐ญ ๐ข๐ฌ ๐๐๐๐?
IRAP is a naturally occurring protein in the horseโs body that blocks the activity of interleukin-1 (IL-1), a potent inflammatory cytokine found in high levels in diseased joints. IL-1 initiates a cascade of inflammation that leads to cartilage breakdown and progressive joint damage. By antagonizing IL-1, IRAP interrupts this damaging inflammatory cycle.
๐ ๐๐จ๐ฐ ๐๐จ ๐ฐ๐ ๐ก๐๐ซ๐ฏ๐๐ฌ๐ญ ๐๐๐๐?
We begin by drawing about 90 mL of blood from your horseโs jugular vein into a specialized syringe containing borosilicate glass beads. The blood incubates for 18-24 hours, stimulating the white blood cells to produce increased levels of IRAP. After incubation, the blood is centrifuged to separate the IRAP-rich serum, which is then prepared in sterile syringes for injection.
๐ฉธ ๐๐จ๐ฐ ๐๐จ๐๐ฌ ๐๐๐๐ ๐ฐ๐จ๐ซ๐ค?
When injected into affected joints or synovial structures, IRAP binds to IL-1 receptors, preventing IL-1 from attaching and triggering the inflammatory process. This targeted blocking reduces inflammation, minimizes pain, and slows progression of degenerative joint disease.
โ ๐๐ก๐ฒ ๐๐จ ๐ฐ๐ ๐ฎ๐ฌ๐ ๐๐๐๐?
We choose IRAP for cases where targeted, natural anti-inflammatory therapy can make the biggest difference in managing joint inflammation and improving your horseโs comfort and performance. Especially in cases like:
โพ Managing mild to moderate osteoarthritis, especially in athletic or aging horses
โพ Horses unresponsive to traditional corticosteroid injections
โพ As a steroid-sparing alternative for metabolic horses and ponies
โพ Support post-surgical joint healing, such as after arthroscopic procedures
โพ For performance horses needing competition-legal joint therapies
๐ ๐๐๐ง๐๐๐ข๐ญ๐ฌ ๐จ๐ ๐๐๐๐:
IRAP provides a natural, targeted approach to joint inflammation with benefits that include:
โพ Uses the horseโs own biological response for a natural anti-inflammatory effect
โพ Minimizes potential side effects seen with repeated steroid use
โพ Can be safely administered multiple times over a horseโs lifetime
โพ Supports improved comfort and joint function, helping extend athletic careers and quality of life
At Signature Equine Hospital, we are dedicated to providing the latest, science-backed treatments like IRAP to support your horseโs joint health and overall well-being. By harnessing your horseโs own natural healing proteins, IRAP offers a safe and effective option to reduce inflammation, relieve pain, and slow the progression of joint disease. IRAP helps your horse stay active, comfortable, and performing at their best for years to come. If you want to learn more about IRAP or see if itโs right for your horse, contact us today!
www.sehtx.com | ๐ฑ 254-968-7898