11/02/2025
FYI: Advil (ibuprofen) can negatively affect the intestines by causing damage such as inflammation, ulcers, bleeding, and even perforation. It can worsen conditions like inflammatory bowel disease, lead to a condition called NSAID enteropathy, and cause a range of symptoms from bloating and gas to more serious issues. These effects happen because ibuprofen inhibits prostaglandins, which are needed to protect the gastrointestinal tract.
Common and less severe effects
Inflammation: Ibuprofen can cause both inflammation of the stomach (gastritis) and the intestines, sometimes referred to as NSAID enteropathy.
Ulcers: It can lead to the development of stomach and intestinal ulcers.
Bleeding: The presence of ulcers can lead to bleeding.
Digestive upset: You may experience symptoms like indigestion, heartburn, bloating, gas, and abdominal pain.
Serious and potentially life-threatening effects
Perforation: In severe cases, Advil can cause a hole to form in the stomach or intestine, which is a medical emergency.
Strictures: It can lead to the narrowing of the intestine, a condition called stricture, which can require surgery.
Worsening of existing conditions: For those with inflammatory bowel disease, it can trigger a relapse. It can also contribute to complications in diverticular disease.
Malabsorption: Long-term use can lead to a malabsorption syndrome, where the body can't properly absorb nutrients.
Who is at higher risk?
Older adults (over 60)
People with a history of stomach or bowel problems, such as ulcers or bleeding
Individuals using other medications concurrently, such as steroids or blood thinners
Those who take multiple NSAIDs or higher doses for long periods
How to mitigate risks
Talk to your doctor about your risk factors.
They may recommend taking a medication like a proton pump inhibitor (PPI) (e.g., omeprazole, pantoprazole) or misoprostol to help protect your stomach.
If you experience persistent stomach pain, stop taking the medication and consult a healthcare provider immediately
