Onpharma Company

Onpharma Company Onpharma's Onset EZ Pen is the easy choice for buffering. The Onset System is simple to use and allows the clinician to inject and go right to work.

Onpharma's Onset is a revolutionary buffering system that uses Sodium Bicarbonate to raise the pH level of local anesthetic. Onset makes your local anesthetic reliable, predictable and more comfortable for the patient.

03/31/2026

"I can't work without it."

That is Dr. Derek Song, general dentist outside Boston, after three weeks with the Onset EZ Pen.

14 years in practice. Learned about buffering 12 years ago. Thought it was a nice to have, not a must have. His words: he wishes he had started sooner.

What changed his mind? His patients stopped getting the zinging sensation on injection. For a dentist who uses local anesthetic all day long on patient after patient, that kind of feedback adds up fast.

He tried it on himself before using it on his patients. Then bought four more pens. Then his associates started using it too.

That is not a product trial. That is a protocol shift.

If you have been on the fence about buffered anesthesia, Dr. Song was too. For 12 years.

Comment "EZ" for more info.

03/26/2026

To that one patient you can never get numb.

Dr. Falkel ran into a dentist named Ron at Penn Station in New York. Ron had bought the Onset EZ Pen six months earlier after a lecture in Phoenix. Still had not used it.

He was waiting for her. That one patient he had never been able to get numb. The impossible case. The one that would finally prove it worked.

Dr. Falkel's response: if you never got her numb, maybe she is not your patient anymore. Why wait for the special case when every case is special?

The first case you do is the best case. Because you are going to see something you have not seen before. And once you see it, you will wonder why you waited.

If the kit is on your shelf, it is ready to go. So are you.

Comment "EZ" for more info.

03/24/2026

Antibiotics in dentistry do not solve the problem the way they do in medicine.

According to Dr. Falkel, what antibiotics actually do in a dental infection scenario is knock the infection down enough for tissue pH to rise so that standard anesthetic has a better chance of working.

That is not a solution. That is a workaround with a 3-4 day wait built in.

When local anesthetic is buffered to physiologic pH, there is a much better chance of achieving anesthesia even in infected tissue. The procedure can happen right away.

And the less frequently antibiotics are prescribed in dentistry, the less opportunity bacteria have to develop resistance. Better for the patient in the chair and for the population overall.

Comment "EZ" for more info.

03/22/2026

Dentists can save time by focusing on quality time.

When you administer buffered local anesthetic and go right to work, something interesting happens. The patient feels like you spent more time with them. But you actually spent less.

No stepping out. No bouncing between operatories. No variable wait time built into the schedule. You sit down, you work, you finish, and you move on.

As Dr. Falkel describes it, the value of the visit goes up when you see, treat, and release. The patient walks out feeling like they received more attention than they ever have. The practice walks away with recovered time in the schedule.

That is not a compromise between efficiency and experience. That is both at the same time.

Comment "EZ" for more info.

03/20/2026

Instead of meeting patient expectations, what if you exceeded them every time?

That is the question buffered anesthesia raises.

Most patients have never experienced it. Most practices have never offered it. And when you have not seen both sides of that comparison, it is difficult to understand how different the two can feel.

Dr. Falkel puts it simply - if you are going to compare buffered to unbuffered anesthetic, there is just no comparison. Not for the patient. Not for the practice.

That is not just a clinical consideration. That is a patient experience conversation worth having.

Comment "EZ" for more info.

03/18/2026

"I have no idea what you're doing, but if you can repeat that, I can get you an extra hour and a half to two hours a day."

That was the practice management consultant watching Dr. Falkel work after switching to buffered anesthesia.

No waiting. No bouncing between operatories.

Administer buffered local anesthetic, go right to work.

Patient comfortable for the injection and comfortable for the procedure, start to finish.

Dr. Falkel took those recovered hours and went from five days a week to three. Same production. Less time in the chair.

That is what a protocol change truly looks like in practice.

Comment "EZ" for more info.

03/16/2026

Dr. Hale has been using Onset for two weeks - here's what he noticed:

More patients seen. Less time spent waiting. And a better experience for everyone in the chair.

This is what buffered anesthesia does in practice.

Comment "EZ" for more info 📝

03/15/2026

Dental school taught Dr. Mic pharmacology, injection techniques, ways to reduce injection pain.

But they never taught him about latency - the time between injection and when the patient is actually numb.

The textbooks said one thing. Real life was different.

When it took longer than expected (which happened most of the time), Dr. Mic felt like he was failing as a dentist.

"I thought I was doing something wrong," he says.

Turns out, latency variability is normal with standard anesthetic. But buffering controls that variability.

Having that option in his early years would have changed everything - less second-guessing, more confidence, better patient experience.

New dentists don't have to go through what he did.

Comment "EZ" for more info 📝

One change to your anesthetic protocol. Three things your team will notice.The chemistry behind it is straightforward.St...
03/14/2026

One change to your anesthetic protocol. Three things your team will notice.

The chemistry behind it is straightforward.

Standard local anesthetic is formulated acidic for shelf stability.

That acidity affects tissue response at contact, influences how efficiently the molecule crosses the nerve membrane, and introduces variability when mixing is done manually.

Buffering addresses all three.

Raising the pH closer to physiologic level before delivery is a mechanism well documented in the dental literature.

Onset EZ Pen was designed for consistent use across all injection types.

Not a case-by-case supplement.

A standard of care workflow.

Comment "EZ" below and we'll send you the full clinical breakdown. 📝

03/14/2026

New dentists: if you master local anesthesia, you can compete at any level of dentistry.

When patients get numb fast and feel minimal to no pain, they gain confidence in you. They know they'll be comfortable throughout the procedure.

You can build your entire practice around that experience.

Patients talk. They tell friends about dentists who "don't hurt." They become loyal. They refer.

Many doctors who've made the switch find buffered anesthetic gives them that competitive edge from day one - no learning curve, just better results.

Master the injection, master your practice.

Comment "EZ" for more info 📝

The injection is the moment that defines the entire appointment in your patient's mind.Not the procedure. Not the outcom...
03/12/2026

The injection is the moment that defines the entire appointment in your patient's mind.

Not the procedure. Not the outcome. The needle.

And the discomfort most patients associate with that moment has a chemical cause.

Standard local anesthetic is acidic by formulation. That acidity irritates tissue on contact.

That irritation is what patients carry with them when they decide whether or not to reschedule.

Buffering addresses that at the source by raising the pH closer to physiologic level before the solution ever reaches tissue.

The procedure stays the same. The delivery chemistry changes.

Many doctors report that patients respond differently when buffering is part of their standard protocol. You may find the same.

Comment "EZ" below and we'll send you the full clinical breakdown 📝

03/12/2026

One of Dr. Mic's colleagues didn't believe local anesthetic could be improved.

"I just don't understand how it can be better," he said.

After getting set up with buffered anesthetic, this dentist almost felt guilty - guilty for how much time he was saving compared to before.

He used buffering right up until retirement.

Comment "EZ" for more info 📝

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Onset Buffering System

Chair side buffering using the Onset system is simple to incorporate, easy to use, and will make your local anesthetic better whether you are using Articaine, Lidocaine, Priolocaine or Mepivicaine.

Because local anesthetic is a key part of so many procedures in the dental office, a long-standing question among dental practitioners has been: How can we make our local anesthetic better? Chemistry lies at the heart of the answer. Local anesthetics begin as alkaline solutions, but manufacturers add hydrochloric acid to lower the pH to around 3.5 (or the same as lemon juice) in order to deliver a multi-year shelf life. However, a long-settled principal of parenteral injections is that an injection should be delivered at a pH as close as possible to the pH of the human body, approximately 7.4.

Onpharma gives dentists their first practical way to buffer the local anesthetic cartridge at chair side toward physiologic pH so practitioners no longer have to deliver an injection having the pH of lemon juice.