RS Equine Reproduction LLC

01/15/2026

🐎 IVF vs ICSI in the horse: same genes, different outcomes?

For more than 20 years, ICSI has been the cornerstone of in vitro embryo production in the horse. Since 2022, however, a repeatable and successful conventional IVF protocol has become available — opening new perspectives for equine assisted reproduction.

But an important question remained unanswered:
👉 Does the fertilization method affect embryo quality at the molecular level?

In this study, equine sibling blastocysts produced by ICSI or IVF were analyzed using Full-Length Single-Cell RNA Sequencing (FLASH-seq).

🔬 Key findings:

- Over 11,500 genes identified
- No differentially expressed genes between IVF and ICSI embryos
- Similar cleavage rates between techniques
- Higher blastocyst rates after ICSI, but
- No difference in timing of blastocyst development

📌 Why does this matter?
The absence of transcriptomic differences strongly supports the biological safety of equine IVF, encouraging its use in future clinical and research applications.

Beyond equine reproduction, the horse continues to serve as a valuable model for studying the long-term effects of assisted reproductive technologies, with potential implications for human medicine.

🔗 Read the text here:
https://www.sciencedirect.com/science/article/abs/pii/S0093691X25004753

12/24/2025

Merry Christmas from RS Family to yours!!! 🎄🎅🐎

12/23/2025

12/14/2025

I little bit more about our weekend in Mexico.🐎🐎🐎

12/14/2025

We had a great weekend in Guadalajara/Mexico, exchanging experiences with our Mexican veterinarian friends. Thank you very much.

12/06/2025

Via TechTimes:
"For years, fertilization was taught as a simple race where the fastest s***m reached the egg first and won. But new research has revealed a far more intricate process. Studies now show that the egg actively participates by releasing chemoattractants — chemical signals that guide s***m toward it. Not all s***m respond the same way, suggesting that the egg may “prefer” certain s***m over others based on subtle biological cues.

Research published in journals such as Nature Communications and eLife suggests this selection process is influenced by genetic compatibility. Eggs appear to attract s***m whose genetic makeup best complements their own, increasing the chances of producing a healthy embryo. This could help explain cases of unexplained infertility, where both partners are healthy yet fertilization doesn’t occur — the egg may be selectively avoiding s***m that aren’t an ideal biological fit.

This understanding shifts the narrative of human conception entirely. Fertilization is not a simple competition but a coordinated interaction between egg and s***m, guided by biochemical communication. Rather than the “fastest wins,” it may be the “best match” that succeeds — highlighting the complexity, intelligence, and selectivity embedded in human biology."

11/09/2025

"Diagram showing a horse’s field of vision, including areas of binocular vision, monocular vision, marginal sight, and blind spots."

10/24/2025

Why Botupharma USA has 5 options of semen Extenders? Explanation down below 👇🏻

10/16/2025

07/24/2025

Take Aim at Uterine Imbalance with BotuKiller

BotuKiller is a targeted uterine infusion designed to disrupt biofilm and support reproductive health in mares. It's been shown to be highly effective when added to mare cleansing protocols.

Article Highlights:
•⁠ ⁠Uterine sanitizer had inhibitory properties against bacteria and yeast.
•⁠ ⁠Escherichia sp. was the most susceptible, and Pseudomonas sp. was the most resistant.
•⁠ ⁠The dilution of antibiotics in uterine sanitizer was stable.

Lock onto the latest study in the Journal of Equine Veterinary Science https://www.sciencedirect.com/science/article/abs/pii/S0737080624001692?via%3Dihub

For more research on BotuKiller or other Botupharma products, explore the full research library here: https://bit.ly/4g5u8UH

07/10/2025

Today was an interesting day at RS Equine, we analyzed Buck semen. 🐐

07/10/2025

Today was an interesting day at RS Equine, we analyzed Buck semen. 🐐