04/15/2026
Can we really trust MRI to rule out seminal vesicle invasion?
Our recent study challenges that assumption and more importantly, shows what to do about it.
What we found MRI has very high specificity (99%) but poor sensitivity (~17%) for SVI 83% of SVI cases are missed on imaging
Key predictors go beyond MRI:
Basal tumor involvement on biopsy
Higher PSA and % positive cores
Grade Group ≥3
MRI indirect signs (ECE, lesion
location) Why it matters clinically
A negative MRI does NOT exclude SVI. Relying on imaging alone risks understaging and suboptimal surgical planning
The big picture This is a shift from imaging-based decisions to integrated risk assessment.
The future isn’t MRI vs. clinical data-it’s the combination of:
Imaging
Biopsy mapping
Clinical variables
(Soon) genomics and PSMA PET
Bottom line:
If you’re planning surgery or radiation based on MRI alone... you’re probably missing the full story.