MPN Research Foundation

MPN Research Foundation Patient-centric foundation that exists to fund research & improve outcomes for those living with MPNs Driving groundbreaking research. Improving lives.

Founded by patients for patients, MPN Research Foundation is a catalyst for research funding in pursuit of new treatments – and eventually a cure – for polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF) – blood cancers collectively known as myeloproliferative neoplasms (MPNs). To date, we have funded more than $18 million in MPN research. Through a combination of MPN cancer research, advocacy and education, we bring together patients, researchers, and clinicians around the common goal of realizing new treatment options and ultimately, a cure for MPNs.

📢 Today is the day!Join us at 5 PM CT for our next MPN Pathways: Empowered Voices in Research Webinar — Clinical Trial P...
11/20/2025

📢 Today is the day!

Join us at 5 PM CT for our next MPN Pathways: Empowered Voices in Research Webinar — Clinical Trial Protocol 101

Discover how clinical trial protocols are designed and how YOU can influence them.

🎤 Expert advocate Jane Perlmutter, Ph.D., MBA will guide you through Clinical Trial Protocol 101.
📅 TODAY Nov. 20 | 5–6 PM CT
✅ Register now to attend live or get the recording: https://goto.mpnresearchfoundation.org/48KyxMQ

Your voice matters. Your feedback can shape research. Don’t miss this chance to make an impact!

“Excitement,” says 2024 MPN Challenge™ award recipient Dr. Robert Kralovics. “Every new batch of data is one little step...
11/19/2025

“Excitement,” says 2024 MPN Challenge™ award recipient Dr. Robert Kralovics. “Every new batch of data is one little step forward.”

Your support keeps that excitement alive.

This fall, his team at the Medical University of Vienna shared important new insights into how the immune system responds to mutated calreticulin (mutCALR) — a key driver of some MPNs.

After studying more than 130 patients, they found that naturally occurring antibodies called anti-mutCALR IgG did not slow cancer cell growth as expected. “Anti-mutCALR IgG level did not impact the mutant CALR clone size or CALR allelic burden,” the report noted.

For Dr. Kralovics, even unexpected results are valuable. “It just shows that MPN is not a simple thing. Nothing is easy — but every new batch of data shows one little step forward.”

Now his team is testing next-generation antibodies that help immune cells better recognize and destroy MPN cells — research that could lead to more effective, immune-based therapies.

Every step counts. You can help move the next discovery forward.

👉 Make an Online Donation: https://goto.mpnresearchfoundation.org/4nBJZOE

Behind every breakthrough are real people. From patients and caregivers to researchers, clinicians, and the biopharmace...
11/17/2025

Behind every breakthrough are real people.

From patients and caregivers to researchers, clinicians, and the biopharmaceutical industry, we are relentless in the fight for better outcomes for those living with essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).

We were proud to represent the MPN community on a global stage by:
👉sparking critical discussion about disease progression and unmet needs of patients & caregivers at 17th International MPN Congress.
👉introducing the MPN PROGRESSion Registry at CR&T Patient Symposium on MPNs.
👉bringing scientific and medical expertise to MPN Horizons.

And in December, we’re presenting at the American Society of Hematology (ASH)’s Annual Meeting to continue to advocate for health disparities faced by essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) patients around the world.

The year is winding down, but we are not. With your support, we are determined to finish the year strong by raising $2 million for MPN research.

Will you help us close the gap and donate today? https://goto.mpnresearchfoundation.org/4nBJZOE

Together, individual drops of data can make an ocean of change. 📢 Did you hear!? The MPN PROGRESSion Registry™ is OPEN ...
11/05/2025

Together, individual drops of data can make an ocean of change.

📢 Did you hear!? The MPN PROGRESSion Registry™ is OPEN for enrollment!

If you are 18 and older, live in the U.S., and have ever been diagnosed with a myeloproliferative neoplasm (MPN), you are invited to join this new, patient-focused research initiative.

The MPN PROGRESSion Registry will track patient health records, genetic tests, treatments, and patient experiences over the next 5 to 10 years — striving to become the most comprehensive, longest-term collection of MPN patient health data in the United States — to answer a critical question: Why do MPNs progress, and what can we do to slow, stop, or reverse that progression.

Participate for PROGRESS!

Your data is part of the solution, and every patient’s experience matters in the effort to expand MPN understanding. It’s easy, secure, and requires minimal time commitment.

Learn more, enroll, and share with your network today. https://goto.mpnresearchfoundation.org/3VSmaqq

11/04/2025

From subtle changes to more noticeable signs, MPNs can look different for each person. Want to understand what to look out for? 🎬 Watch the FULL animation at YouAndMPN.com to learn more!

YouAndMPN.com is a new, free educational program designed to help patients and caregivers better understand MPNs and feel empowered in their care.

Developed by the MPN Research Foundation in collaboration with Mechanisms in Medicine Animated Patient

11/03/2025

From subtle changes to more noticeable signs, MPNs can look different for each person. Want to understand what to look out for? 🎬 Watch the FULL animation at YouAndMPN.com to learn more!

You and MPN is a new, free educational program designed to help patients and caregivers better understand MPNs and feel empowered in their care.

Developed by in collaboration with Mechanisms in Medicine /

Did you know that you can help us fund research for myeloproliferative neoplasms by enjoying your favorite meals? ️ Wit...
11/02/2025

Did you know that you can help us fund research for myeloproliferative neoplasms by enjoying your favorite meals? ️

With HungryFriend, 4% of every meal at participating restaurants is donated directly funding groundbreaking research in pursuit of new treatments — and cures — for , , and .

Download the app by clicking here: https://dashboard.hungryfriend.net/user/get-started?org_id=557

Start on-the-go and get a $5 gift card for signing up!

Want to keep up-to-date on other ways to get involved in the Foundation? Join our community today: https://goto.mpnresearchfoundation.org/4gBU3o9

The MPN PROGRESSion Registry™ is open for patient enrollment. 🔬 This patient-focused research initiative gathers compreh...
10/30/2025

The MPN PROGRESSion Registry™ is open for patient enrollment. 🔬

This patient-focused research initiative gathers comprehensive myeloproliferative neoplasm (MPN) patient health data over 5-10 years to help researchers answer vital questions about MPNs.

In keeping with our commitment to safe, successful, ethical research — and a critical part of the enrollment process — each patient must provide their informed consent to participate.

What is informed consent?
The process of providing potential participants with complete and transparent study information, ensuring the risks, benefits, alternatives and details are clear so you can voluntarily decide whether to enroll.

This information is provided on the MPN PROGRESSion Registry™ webpage, and throughout the enrollment process on our secure Registry portal.

We have also produced an informed consent video with MPN PROGRESSion Registry principal investigator, Dr. Raajit Rampal, physician and researcher at Memorial Sloan Kettering Cancer Center. Dr. Rampal outlines what the Registry is, why it matters, and what participation involves. He walks you through informed consent by highlighting key points and answering common questions, so you know exactly what to expect.

Your experience matters and adds to a growing body of knowledge that can support better research and improve care.

🌟Lean more, watch the informed consent video and enroll today! 🌟 https://goto.mpnresearchfoundation.org/434w3VJ



Join Us for Clinical Trial Protocol 101!Ever wondered how clinical trials are designed or how YOU can help shape them?Wh...
10/28/2025

Join Us for Clinical Trial Protocol 101!

Ever wondered how clinical trials are designed or how YOU can help shape them?

Whether you're living with a myeloproliferative neoplasm (MPN) or supporting someone who is, this free webinar is a part of our webinar series that will empower you to be an informed and active participant in research.

🗓️ Date: Wednesday, Nov. 20, 2025
🕔 Time: 5–6pm CT
🎙️ Speaker: Jane Perlmutter, Ph.D., MBA – Expert Advocate

What you’ll learn:
What a clinical trial protocol is and why it matters
How to review protocols from a patient/caregiver perspective
Ways to provide feedback during protocol development

👉 Register now: https://goto.mpnresearchfoundation.org/48KyxMQ
Can’t make it live? No worries! All registrants receive access to the recording and post-session materials

10/27/2025

The MPN PROGRESSion Registry™ is now OPEN for patient enrollment! 🚦

Are you a patient, 18 or older and living in the U.S. who has ever been diagnosed with an MPN? You can help impact future MPN research! Participation is easy, secure, and requires minimal time commitment.

This new, patient-focused research initiative gathers comprehensive myeloproliferative neoplasm (MPN) patient health data over 5-10 years. The goal is to help provide better understanding of MPNs and why they can progress from one disease to another, or more rarely, to secondary acute myeloid leukemia (sAML).

By participating, you’ll help researchers and clinicians:
🔬 Better understand what causes progression: when MPNs progress to more aggressive forms of the disease
🔬 Discover new treatments and care strategies
🔬 Measure how well care treatments work
🔬 Move us closer to a cure for MPNs

Your data is part of the solution, and every patient matters.

Learn more and enroll today! https://goto.mpnresearchfoundation.org/3VSmaqq

Our team is here to help you with enrollment and your ongoing participation. Email us at: research@mpnrf.org

10/20/2025

How do myeloproliferative neoplasms (MPNs) develop?
Inside your bones, the bone marrow works like a factory, producing just the right number of blood cells. But sometimes, that factory gets the wrong instructions and starts making too many of one type of blood cell. This can lead to MPNs.

👉 Watch the FULL animation at YouAndMPN.com to learn more!

You and MPN is a free educational resource designed to help patients and caregivers better understand MPNs and feel empowered in their care.

Developed by the MPN Research Foundation with Mechanisms in Medicine Animated Patient

10/20/2025

How do myeloproliferative neoplasms (MPNs) develop?

Inside your bones, the bone marrow works like a factory, producing just the right number of red blood cells, white blood cells, and platelets. But sometimes, that factory gets the wrong instructions and starts making too many of one type of blood cell. This can lead to MPNs.

👉 Watch the FULL animation at YouAndMPN.com to learn more!

You and MPN is a new, free educational program designed to help patients and caregivers better understand MPNs and feel empowered in their care.

Developed by the in collaboration with Mechanisms in Medicine /
Thank you to our sponsors , , GSK, Incyte, Merck,

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Chicago, IL
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