JAMA Cardiology

JAMA Cardiology JAMA Cardiology is a member of the JAMA Network, a consortium of peer-reviewed publications

JAMA Cardiology’s new Editor in Chief, Barbara Casadei, MD, DPhil, FMedSci, highlights JAMA Cardiology’s commitment to b...
03/13/2026

JAMA Cardiology’s new Editor in Chief, Barbara Casadei, MD, DPhil, FMedSci, highlights JAMA Cardiology’s commitment to bridging clinical science and public health through rigorous research, innovation in diagnostics and therapeutics, and promotion of cardiovascular disease prevention.

https://ja.ma/4aZdcPg

💬 Editorial: Robert O. Bonow, MD, MS, reflects on the first decade of JAMA Cardiology, detailing the journal’s developme...
03/12/2026

💬 Editorial: Robert O. Bonow, MD, MS, reflects on the first decade of JAMA Cardiology, detailing the journal’s development from its inception, the initial challenges encountered, and its subsequent growth in reach and impact.

https://ja.ma/4062eCv

💬 Editorial: The HeartSync-LBBP trial demonstrated greater reductions in heart failure hospitalization and improvements ...
03/11/2026

💬 Editorial: The HeartSync-LBBP trial demonstrated greater reductions in heart failure hospitalization and improvements in left ventricular ejection fraction (LVEF) with conduction system pacing compared to biventricular pacing, primarily among selected patients and experienced operators.

In contrast, PhysioSync-HF reported inferiority of CSP, with less improvement in LVEF, possibly due to heterogeneous pacing techniques and lower operator experience. These results suggest that CSP may benefit highly selected patients, but its broader adoption requires evidence from appropriately powered trials with clinically meaningful endpoints.

https://ja.ma/4rIVnKN

In the PhysioSync-HF randomized clinical trial, conduction system pacing ( ) was inferior to biventricular pacing ( ) fo...
03/11/2026

In the PhysioSync-HF randomized clinical trial, conduction system pacing ( ) was inferior to biventricular pacing ( ) for patients with heart failure, left bundle-branch block ( ), and reduced left ventricular ejection fraction ( ) over 12 months.

CSP was associated with higher odds of death, heart failure hospitalization, urgent visits, and smaller improvements in LVEF compared to BiVP.

Complication rates and procedural-related deaths were also higher with CSP, and the efficacy of the intervention may have been influenced by heterogeneous operator experience and diverse pacing techniques.

https://ja.ma/4bnozRb

Among patients with heart failure and LBBB, LBBP demonstrated superior long-term clinical outcomes compared to BiVP, dri...
03/11/2026

Among patients with heart failure and LBBB, LBBP demonstrated superior long-term clinical outcomes compared to BiVP, driven primarily by reduced rates of heart failure hospitalization.

Both groups showed improvements in and functional status, but the proportion of super responders was greater with LBBP. The high success rate and low complication profile in the LBBP group were attributed to experienced operators and a population predominantly with nonischemic cardiomyopathy.

https://ja.ma/3OTKQyF

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement...
03/09/2026

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

https://ja.ma/4bcJyWD

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement...
03/08/2026

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

https://ja.ma/4sxkn8t

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke...
03/07/2026

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention.

https://ja.ma/4rVu4xs

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement...
03/05/2026

Genotype-positive in US adults was linked to higher atherosclerotic cardiovascular disease rates and lower achievement of guideline-recommended LDL-C targets.

https://ja.ma/3MW7ohh

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke...
03/04/2026

Higher aldosterone-renin ratios in older adults were linked to increased risk of atrial fibrillation and ischemic stroke, supporting the aldosterone pathway as a target for cardiovascular disease prevention.

https://ja.ma/4rIskre

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (
03/02/2026

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (
03/01/2026

At 20-year follow-up after patent foramen ovale closure for paradoxical embolism, recurrent stroke was rare (

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