JAMA Cardiology

JAMA Cardiology JAMA Cardiology is a member of the JAMA Network, a consortium of peer-reviewed publications

Statin therapy before and during anthracycline-based chemotherapy resulted in fewer cases of elevated pulse wave velocit...
01/26/2026

Statin therapy before and during anthracycline-based chemotherapy resulted in fewer cases of elevated pulse wave velocity and reduced aortic distensibility compared with placebo. The results suggest a potential protective effect of atorvastatin against vascular dysfunction in cancer survivors. https://ja.ma/3LNvvOS

Women with moderate-severe had higher mortality under medical management, underscoring the need for sex-specific thres...
01/25/2026

Women with moderate-severe had higher mortality under medical management, underscoring the need for sex-specific thresholds for left ventricular remodeling. https://ja.ma/4sWTMCz

💬 Editorial: Stroke risk classification that relies solely on carotid stenosis severity overlooks patients with nonobstr...
01/25/2026

💬 Editorial: Stroke risk classification that relies solely on carotid stenosis severity overlooks patients with nonobstructive but high-risk carotid plaques, underestimating the true contribution of carotid disease to ischemic stroke.

Recent European Society of Cardiology guidelines and Carotid Plaque–RADS offer improved risk stratification by accounting for plaque features, with evidence showing significant gains in predictive accuracy.

https://ja.ma/4sVWkRs

Acoramidis confers consistent reductions in all-cause mortality and cardiovascular hospitalization in both wild-type and...
01/24/2026

Acoramidis confers consistent reductions in all-cause mortality and cardiovascular hospitalization in both wild-type and variant ATTR-CM groups, including those with the p.Val142Ile variant. Long-term data through 42 months support durable benefits for diverse patient populations. https://ja.ma/4qWuQdn

Among adults participating in a structured remote management program, one-third transmitted no blood pressure readings...
01/22/2026

Among adults participating in a structured remote management program, one-third transmitted no blood pressure readings during the initial measurement period, and 47% failed to meet minimum measurement criteria to advance medication titration.

https://ja.ma/4bhxqWl

Moderate to vigorous physical activity (MVPA) is associated with lower risks of atrial fibrillation, heart failure, myoc...
01/22/2026

Moderate to vigorous physical activity (MVPA) is associated with lower risks of atrial fibrillation, heart failure, myocardial infarction, and stroke across both carriers and noncarriers. MVPA did not increase risk of ventricular arrhythmia or promote pathologic cardiac remodeling in asymptomatic carriers.

https://ja.ma/49yMQEj

In a multicenter cohort study of adults with moderate-severe and preserved ejection fraction, women experienced higher...
01/21/2026

In a multicenter cohort study of adults with moderate-severe and preserved ejection fraction, women experienced higher mortality under medical management compared to men.

The optimal left ventricular end-systolic diameter index threshold associated with mortality was similar for both sexes (≥20 mm/m²), while volumetric thresholds differed: 40 mL/m² for women and 45 mL/m² for men.

These findings support the use of sex-specific thresholds to improve risk stratification and timing of intervention.

https://ja.ma/4b4p9EZ

💬 Editor's Note: Herraiz-Adillo et al report that stage 2 hypertension and even modestly increased systolic blood pressu...
01/21/2026

💬 Editor's Note: Herraiz-Adillo et al report that stage 2 hypertension and even modestly increased systolic blood pressure in young adulthood are independently associated with severe coronary stenosis in midlife.

https://ja.ma/4sNKIQw

and drive a high risk of adverse outcomes, but anti-inflammatory strategies remain limited. 📢 This Special Communica...
01/20/2026

and drive a high risk of adverse outcomes, but anti-inflammatory strategies remain limited.

📢 This Special Communication describes the ZEUS trial, which will determine whether interleukin-6 inhibition with ziltivekimab reduces heart and kidney events in patients with atherosclerotic disease, chronic kidney disease, and systemic inflammation.

https://ja.ma/49A2kq8

A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results...
01/19/2026

A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR troponin T levels.

What would you do next? https://ja.ma/4jKtUpn

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered wi...
01/19/2026

In 152 male marathon runners, right ventricular ejection fraction declined transiently after a marathon but recovered within 3 days and remained stable at 10-year follow-up. https://ja.ma/4jK6QqQ

Among patients with severe symptomatic aortic stenosis at low to intermediate surgical risk, transcatheter aortic valve ...
01/18/2026

Among patients with severe symptomatic aortic stenosis at low to intermediate surgical risk, transcatheter aortic valve implantation was associated with a lower 1-year risk of all-cause death or any stroke. https://ja.ma/4pOEvBh

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