JAMA Cardiology

02/19/2026

A previously healthy female teenager presents with chest tightness and syncope after exertion. Electrocardiogram results showed ST-segment elevation in leads V1 through V4, aVL, and aVR, and laboratory results indicated elevated cardiac troponin T levels.

What would you do next? https://ja.ma/4a6uWsV

02/18/2026

💬 Editorial: Adverse pregnancy outcomes, especially hypertensive disorders, are linked to higher risk of premature . Pregnancy presents a key window for CV risk assessment and counseling.

Pregnancy is well recognized as a critical period in a woman’s life course when physiologic changes intended to support the growing fetus can have adverse sequelae for long-term cardiovascular health.1 Adverse pregnancy outcomes are rising in prevalence, complicate nearly 1 in 5 pregnancies in the...

02/18/2026

In a population-based cohort, third-trimester levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and high-sensitivity cardiac troponin I were independently associated with greater long-term risk in pregnant women.

https://ja.ma/4tB6Td6

02/18/2026

is the most prevalent valvular disorder in the US and is associated with adverse outcomes if left untreated.

This narrative review describes current guidelines for intervention in severe primary mitral regurgitation and explores an approach that incorporates additional injury assessment, novel imaging markers, and biomarkers to optimize surgical timing.

https://ja.ma/3ZgcbNq

02/17/2026

Monthly subcutaneous SHR-1918, a fully human monoclonal antibody targeting ANGPTL3, was associated with reduced LDL-C in adults with homozygous familial on stable lipid-lowering therapy.

https://ja.ma/4bAd9LD

02/16/2026

Changing from high-sensitivity cardiac troponin I to T assay doubled myocardial injury detection and admissions, without improving 1-year cardiovascular outcomes in suspected .

https://ja.ma/3Mg0Zx4

02/15/2026

Among patients with diabetes and multivessel coronary artery disease, ticagrelor was not noninferior to prasugrel for reducing death, myocardial infarction, stroke, or major bleeding at 1 year after percutaneous coronary intervention.

https://ja.ma/4tCjJrr

02/15/2026

Very high lipoprotein(a) levels are associated with increased 30-year risk of major events, coronary heart disease, ischemic , and cardiovascular death among healthy women.

https://ja.ma/4kjD5gU

02/14/2026

In symptomatic patients without known coronary disease, -derived plaque burden and volume independently predicted MACE beyond clinical risk and standard imaging findings.

https://ja.ma/4cu9qzF

02/14/2026

In the Sarcomeric Human Cardiomyopathy Registry, lower household income and higher social deprivation index were each associated with higher rates of heart failure, arrhythmias, and mortality in .

https://ja.ma/3NVOJ5B

02/14/2026

From JAMA: The US Food and Drug Administration recently cleared the Apple Watch notification feature.

Researchers applied performance metrics reported by Apple to nationally representative survey data and found that, overall, 69% of individuals who receive a smartwatch alert would have hypertension, while 79% of those who do not receive an alert would not have hypertension. However, these rates vary according to subgroup characteristics, such as age and s*x.

Current guidelines recommend cuff-based blood pressure measurement as the standard for diagnosing hypertension. Incorporating cuffless device technologies into public health screening efforts will require additional validation and careful attention to device accuracy to reduce misclassification and the risk of false reassurance.

https://ja.ma/4qArqMc

02/13/2026

Among patients with supraventricular tachycardia, use of a handheld Valsalva assist device resulted in greater rates of sinus rhythm restoration compared with the standard Valsalva maneuver (63% vs 29% within 1 minute after up to two attempts).

https://ja.ma/3Zvf9h5