02/04/2026
If you've experience this, you're not crazy.
Not all GLP1 side effects are gastrointestinal. That's because GLP1 medications don't just work in your gut, they also work in your brain, especially in the areas tied to dopamine and reward
Two often overlooked, interesting side effects are anhedonia and dysesthesia.
✨Anhedonia is that numb, "blah" feeling. You're not depressed or necessarily sad, you just don't feel excited about things that normally bring you joy.
A scientist whose work in the 1970s helped pioneer modern GLP1 medications like Ozempic has even expressed concern that long-term use may be difficult, because "Once you've been on this for a year or two, life is so miserably boring that you can't stand it any longer and you have to go back to your old life." -Professor Jens Juul Holst
✨Dysesthesia refers to abnormal nerve sensations that shouldn't be there, like burning, tingling, pins-and-needles, or crawling sensations.
Have you experienced either of these, or any other unexpected side effects?👇