11/11/2025
Low Choline Could Be a Hidden Driver of Anxiety
Researchers reviewing 25 brain-imaging studies found an 8% drop in choline levels among people with anxiety disorders compared to those without anxiety.
This pattern was strongest in the prefrontal cortex, a hub for regulating thoughts, emotions, and behavior.
The results suggest that anxiety may involve measurable metabolic imbalances, not just psychological or behavioral factors.
The work opens the door to exploring whether dietary choline or other metabolic interventions could support brain health in anxiety.