03/24/2026
๐ SCIENTIFIC ARTICLE OF THE MONTH:
Impact of combining dexmedetomidine with either acepromazine or atropine on sedation quality & cardiopulmonary values in dogs ๐
Do you pre-medicate with an anticholinergic (either atropine or glycopyrrolate) before administering dexmed? Have you also ever thought to combine both sedatives - ace & dexmed - together in the hopes of improving either sedation or cardiovascular impacts?
Well this study might make you think twice about that comboโฆ ๐คจ๐
This study is just one of many that shows how detrimental the pre-administration of anti-cholinergics prior to dexmedetomidine (alpha2-agonist) administration can be ๐ซฃ While many worry about the bradycardia that occurs from dexmed administration, we must all remember that this is a REFLEX-bradycardia that the body does on purpose to counteract the vasoconstriction & systemic hypertension that occurs from dexmed ๐๐ It is only appropriate to consider anticholinergic administration once the vasoconstriction has subsided and the patient then becomes hypotensive amidst concurrent bradycardia ๐๐
For those familiar with Zenalpha (medetomidine+vatinoxan) being a similar combo to dexmed+acepromazine, this was an early study before Zenalpha hit the shelves to potentially show how the contrasting alpha-receptor profiles may โminimizeโ cardiovascular effects. However, this study and Zenalpha-studies have shown that there ultimately can still be an overall negative effect on cardiac output (especially when inhalants are included) ๐
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As you can see, there are no appreciable benefits to combining these drugs in this manner ๐ This study is a great example of how understanding the receptors your anesthetic drugs work at (yay for pharmacology!) makes it SO much easier to know what effects to anticipate ๐ฉ๐ปโโ๏ธ๐๐
Reach out to us if youโd like to understand more about the relationship between dexmedetomidine, acepromazine, and anticholinergics ๐ฉ
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