JAMA

04/24/2026

Med News: In newly updated guidance, the American Heart Association advises shifting from meat to a plant-based diet for improved health.

The recommendations also highlight the importance of focusing on healthy dietary patterns over individual foods and nutrients and advise starting heart-healthy eating early in life.

Find out more:

This Medical News article discusses the American Heart Association’s new scientific statement on dietary guidance to improve cardiovascular health.

04/24/2026

Med News: New research suggests that , a common , may help reduce use.

A phase 3 clinical trial found that mirtazapine provided modest but potentially meaningful reductions in use among people with methamphetamine use disorder.

Here’s what to know about this possible new treatment option.

This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.

04/24/2026

📊 Research Summary: Among patients with multiorgan metastatic , tumor debulking combined with systemic chemotherapy failed to provide a survival benefit over chemotherapy alone and resulted in higher rates of serious adverse events.

https://ja.ma/4eBGI0L

04/24/2026

In patients with early septic shock, the ANDROMEDA‑SHOCK‑2 randomized clinical trial evaluated a personalized hemodynamic resuscitation protocol targeting normalization of capillary refill time. Compared with usual care, this strategy was superior for a hierarchical composite outcome of mortality, duration of vital support, and length of hospital stay at 28 days, with the overall benefit primarily attributable to a shorter duration of organ support.

JAMA and JAMA Network Editor in Chief Kirsten Bibbins‑Domingo, PhD, MD, MAS, selected this study as one of her favorite trials of 2025, citing its physiologically grounded design, use of scalable bedside assessments, and extensive international investigator collaboration. The trial illustrates how personalized resuscitation strategies can be rigorously evaluated across diverse clinical settings.

JAMA+ Trials highlights the implications and innovations of clinical trial research from across the JAMA Network to advance evidence-based medicine and public health. Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources.

📬 Sign up for the JAMA+ Trials email newsletter: https://ja.ma/4e2Hu6T

📖 Read the full trial: https://ja.ma/4cGOOTk

04/24/2026

💡 JAMA Insights: Numerical risk comparisons guide shared decision-making by helping patients evaluate treatment options and understand clinical risk.

Providing risk statistics alongside relevant comparators, such as treatment vs no treatment or different therapy choices, improves clarity and supports informed patient decisions. Clinicians should use absolute formats, anchor comparisons in the patient’s situation, and transparently convey available alternatives to enhance comprehension and support patient-centered care.

https://ja.ma/4tAAgMq

04/24/2026

💬 Viewpoint by Harry Ostrer, MD: Rare genetic diseases collectively place a major burden on children, and pediatric care must be redesigned to provide earlier genomic diagnosis, coordinated management, and equitable access to emerging therapies.

https://ja.ma/4mO2SiC

04/23/2026

"Medicine was not something I did between 9 AM and 5 PM. It was not something that sat on one side of a scale opposite of 'life.' Medicine was woven through every aspect of my life."

In , a retired family physician reflects on the boxes of paper left behind by a medical career—and the enduring relationships, lessons, and identity they represent.

https://ja.ma/4tmIiZ0

04/23/2026

💬 Viewpoint: A 5-year extension of the Acute Hospital Care at Home waiver enables continued reimbursement for , a model that delivers hospital-level care in patients’ homes.

Evidence from clinical trials and early waiver experience indicates lower hospital-associated complications, better patient experience, and lower costs compared with traditional inpatient care.

The extension provides a stable policy window to scale home-based acute care and evaluate its role in future Medicare payment and quality frameworks.

https://ja.ma/4ctgn3D

04/23/2026

Why can signals that appear consistent across many studies still reflect shared ? How do sibling comparisons help recalibrate cumulative evidence? What -enabled approaches can add to large-scale evidence integration?

Viktor H. Ahlqvist, PhD, from the Karolinska Institutet joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss why automated drug safety surveillance during is urgently needed and how and can strengthen or undermine causal inference.

JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Viktor H. Ahlqvist, PhD, a postdoctoral fellow in the Unit of Integrative Epidemiology of the Institute of Environmental Medicine at Karolinska Institutet, for JAMA+ AI Conversations.

04/23/2026

Benign paroxysmal positional vertigo (BPPV) is an inner ear disorder that causes brief episodes of vertigo, which is a spinning sensation that occurs without movement.

This JAMA Patient Page describes common symptoms and causes of benign paroxysmal positional vertigo, risk factors, and diagnosis and treatment.

https://ja.ma/4cGPdVE

04/23/2026

Benign paroxysmal positional vertigo ( ) is a common peripheral vestibular disorder, particularly among older adults, and is caused by dislodged otolith particles within the semicircular canals.

Diagnosis relies on identifying transient, positionally triggered nystagmus using the Dix-Hallpike test.

📊 This JAMA Insights discusses the epidemiology, clinical presentation, and diagnostic evaluation of benign paroxysmal positional vertigo. https://ja.ma/4tt8gtQ

04/23/2026

💬 Editorial: Analysis of the Oncology Care Model indicates that episode savings increased over time, primarily through changes in supportive care medication use, while hospital utilization remained unchanged.

Practices committed to two-sided risk generated most savings, yet aggregate results were diluted by practices without meaningful accountability. Rapid policy shifts based on interim analyses contributed to low participation in the new Enhancing Oncology Model.

Future models should differentiate committed practices, invest upfront in care transformation, and adapt quickly to robust evidence for sustainable value-based care.

https://ja.ma/3OT8cEM