JAMA

JAMA is an international peer-reviewed general medical journal published weekly online and in print.
(1590)

The official page for JAMA http://jama.com, an international, peer-reviewed journal published weekly online and in print.

01/08/2026

Prostatitis involves infection, inflammation, or pain in the prostate gland and affects about 9% of men during their lifetime.

Patients with acute prostatitis typically have fever, chills, pelvic pain, sudden onset of frequent urination, and pain or burning during urination.

📄 This JAMA Patient Page describes the types of prostatitis and its risk factors, diagnosis, and treatment.

https://ja.ma/3LyUHII

01/08/2026

Kendra D. Sims, PhD, postdoctoral associate in epidemiology, Boston University, discusses Tipping Point Analysis: Assessing the Potential Impact of Missing Data with JAMA Statistical Editor Roger J. Lewis, MD, PhD. https://ja.ma/4aItnSG

01/08/2026

Stillbirth affects approximately 5.7 per 1000 births in the US and can occur antenatally (83%) or intrapartum (17%).

Modifying known maternal risk factors and utilizing risk-appropriate antenatal testing can help reduce the incidence of stillbirths. However, current approaches to preventing stillbirth are limited by the unexplained nature of many stillbirths and the difficulty identifying pregnancies at highest risk.

💡 This JAMA Insights focuses on , including causes, risk factors, and preventive care.

https://ja.ma/4qMAdLG

01/08/2026

An interim analysis of a retrospective cohort study found that vaccination in , given between 32 and 36 weeks’ gestation, was not associated with increased risk of preterm birth, hypertensive disorders of pregnancy, premature rupture of membranes, or preterm rupture of membranes.

After robust confounding adjustment and 1:1 matching, safety outcomes for RSVpreF-vaccinated and unvaccinated pregnancies were similar.

https://ja.ma/49wz0kF

01/08/2026

📊 Research Summary: Adding acetaminophen (paracetamol) or hydromorphone to ibuprofen did not improve pain relief for children with acute limb injuries; hydromorphone led to more adverse events.

https://ja.ma/3NlBNWd

01/08/2026

💬 Editorial: Randomized clinical trials by Ali et al found no incremental benefit of hydromorphone + ibuprofen over ibuprofen alone for acute musculoskeletal pain in children and adolescents and highlighted higher rates of adverse events with opioid use.

This evidence supports recommendations that nonopioid medications be the default for pain management in most patients with musculoskeletal injuries.

https://ja.ma/4qCjPgu

01/08/2026

For children with acute nonoperative limb injuries, pain scores did not improve with addition of either acetaminophen (paracetamol) or hydromorphone to ibuprofen; adverse events were higher with hydromorphone.

https://ja.ma/4bjonUE

01/08/2026

💬 Editorial: The LEVOECMO RCT assessed levosimendan for facilitating weaning from venoarterial extracorporeal membrane oxygenation ( ) in patients with potentially reversible cardiogenic shock.

The trial demonstrated no advantage of levosimendan vs placebo for the primary or secondary outcomes, including all-cause mortality. Incidence of ventricular arrhythmias was higher with levosimendan.

https://ja.ma/4qGgBsl

01/08/2026

RCT: Among patients with severe but potentially reversible cardiogenic shock, early administration of levosimendan did not significantly shorten time to successful VA-ECMO weaning.

These findings do not support the routine use of levosimendan to improve outcomes in this patient population.

https://ja.ma/4prKpIg

01/08/2026

Is taking acid-suppressive medications during linked to neuropsychiatric disorders in children?

A nationwide cohort study of more than 2.7 million mother-child pairs in South Korea, published in JAMA, found that prenatal exposure to acid-suppressive medications was not associated with an increased risk of attention-deficit/hyperactivity disorder, autism spectrum disorder, intellectual disability, obsessive-compulsive disorder, or severe neuropsychiatric disorders in sibling-control analyses.

📽️ Watch the video and read the full study: https://ja.ma/3NxI554

01/07/2026

Incidence rates of gastric cancer in younger individuals are on the rise and gastric cancer is the fifth-leading cause of cancer-related deaths worldwide.

JAMA Review author Haeseong Park, MD, MPH, from the Dana-Farber Cancer Institute, discusses this and more with JAMA Senior Editor Karen Lasser, MD, MPH.

https://ja.ma/49pGmpL

01/07/2026

Gastric cancer is the fifth most diagnosed and the fifth leading cause of cancer-related deaths worldwide. Globally, nearly a million new cases and 659 853 deaths from were reported in 2022.

Localized gastric cancer is treated with gastrectomy, and locally advanced disease is treated with surgery, immunotherapy, and chemotherapy. For patients with unresectable or metastatic gastric cancer, use of immune checkpoint inhibitors and targeted therapies, and integration of supportive care, improves survival by several months.

This Review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, and management of gastric cancer.

https://ja.ma/4sD7RoS

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