11/02/2025
The more you know!
It’s interesting how inflammation is the root cause of so much, including throwing off our energy balance, which causes fatigue—sometimes even what’s known as Chronic Fatigue Syndrome. Also called Myalgic Encephalomyelitis (ME/CFS), this condition isn’t just feeling tired—it’s a profound, unrelenting exhaustion that doesn’t improve with rest, often paired with brain fog, muscle pain, and immune dysfunction.
It affects up to 2.5 million people in the U.S. alone, though many cases go undiagnosed. The causes? Immune dysfunction, inflammation, mitochondrial issues, and possibly even Endocannabinoid System (ECS) imbalance.
The ECS directly affects energy regulation, inflammation control, and immune homeostasis—all disrupted in CFS/ME. Low Endocannabinoid levels (like Anandamide and 2-AG) are linked to chronic inflammation and dysregulated nervous system responses, key factors in fatigue-related conditions.
CBD, CBG, and CBGa have been explored for their ability to modulate the immune system, reduce oxidative stress, and support mitochondrial function, which may help restore energy balance. Researchers are now diving deeper into how cannabinoid therapies could become a viable approach for managing chronic fatigue symptoms.
Recent studies back this up:
A 2023 study, "Neuroinflammation and Endocannabinoid Dysfunction in Chronic Fatigue Syndrome," found elevated inflammation markers and low endocannabinoid levels in ME/CFS patients, suggesting ECS dysregulation as a factor.
A 2022 study, "Mitochondrial Dysfunction and Fatigue: Role of the Endocannabinoid System," explored how CBGa and CBD support mitochondrial energy production, potentially counteracting fatigue.
Another 2024 study, "Cannabinoid-Based Therapies for Fatigue Syndromes: A New Frontier," found CBD and THC reduced inflammation and improved energy levels in patients with chronic fatigue symptoms.
The connection is clear: chronic inflammation, ECS imbalance, and mitochondrial dysfunction are all part of the equation, and cannabinoids may help restore balance.
-Mike Robinson, The Researcher OG