10/27/2025
October Post will examine the MTHFR
polymorphism condition.
Frequently, I am requested to assess this condition as a potential cause of treatment-resistant depression, fatigue, brain fog, or difficult-to-control migraine headaches. Rarely, am searching for reasons for blood clots, stroke risk, or cancer development risk. The effects of this gene mutation can be far-reaching. However, with proper management, it does not have to be debilitating for those affected.
MTHFR, a genetic defect involving a Single Nucleotide Polymorphism, affects the body's methylation process by altering the coding for methylene tetrahydrofolate reductase. Methylation is a cellular process where the body attaches a methyl group to a chemical to facilitate breakdown and elimination or to produce hormones and neurotransmitters. The body utilizes methyl groups as a form of energy currency. When this cycle is disrupted, problems arise.
Symptoms associated with MTHFR issues include depression, anxiety, concentration difficulties, body aches, and fatigue, primarily resulting from inflammation caused by the buildup of metabolites and toxins that are not efficiently eliminated. Increased inflammation can lead to heart attacks and stroke, even in individuals with normal lipid profiles.
Treating this condition and monitoring Homocysteine level reduction can decrease the risk of heart disease.
For fatigue and headache management, treatment with methylated vitamin B6 and B12 can enhance methylation, clearing brain fog and headaches.
In cases of depression and mental health concerns, medication efficacy improves, and brain neurotransmitter levels increase.
The first step is to undergo testing. We utilize the MTHFR gene assay in our laboratory and develop a treatment plan based on the results.
There are two primary defect patterns:
C-677T, the more intense form, and
A-1298C, the less intense form.
Lifestyle modifications and supplementation are crucial. However, using the wrong supplement and only partially adopting lifestyle changes can result in suboptimal responses.
Effective MTHFR supplements contain methylfolate and methylcobalamin, along with other beneficial B Complex vitamins. We recommend a specific supplement in our office.
Lifestyle changes to optimize response include:
1) consuming three meals per day for regular fueling.
2) incorporating 70-100g of protein into the diet daily.
3) avoiding starchy vegetables like potatoes and corn.
4) seeking fermented foods such as sauerkraut, kimchi, yogurt, and kefir to support beneficial bacteria in your intestines.
5) using healthy oils like olive, avocado, and coconut oils.
6) avoiding seed oils that raise inflammation,
7) limit enriched and processed foods that contain synthetic folate, which can “plug up” methylation machinery.
8. Reduce alcohol to less than 2 drinks a day. Limit caffeine to 100 mg a day.
9. Avoid highly processed foods. More than 3-5 ingredients, and/or chemical names on the list.
10. Avoid artificial sweeteners. Aspartame, sucralose and saccharin. Stevia is OK.
11. Try avoiding gluten and dairy. Very hard to do.
If your problem won’t budge, this may make the difference.
12. Exercise as weight training and some
cardio. Aim for 30 minutes a day.
Supplements to support methylation.
1. Methyl folate
2. Methyl cobalamin
3. Magnesium malate, or glycinate.
4. Vitamin D3 with K2.
5. Fish oil/omega 3 fatty acids.
A hard to explain condition, that when treated, can improve longevity and decrease suffering.
Hope this was helpful.
Dr. H