04/07/2026
March Post. A week late as took grandkids for Spring Break.
American College of Cardiology/ACC released
their new Heart Disease prevention guidelines.
Interesting take as MDVIP had us doing inflammation markers over 6 years ago. Still nothing real simple like a table that is an easy read.
First off, is trying to clarify/classify people at highest risk for heart attack and stroke. Then applying recommendation on what testing should be done.
Highest risk patients have are this with LDL over 190, known coronary disease, diabetes mellitus, prior stroke, and those with Coronary Calcium Scores over 300. This group gets the most intense treatment with a goal to get LDL below 55 mg/dl.
Those without all of these risks are supposed to do well on less intense treatment. ACC still puts statins like Crestor and Lipitor as their preferred drugs. The higher the risk, the higher the dose.
Left out are items like Bempedoic Acid and Ezetimibe that work well together. Some who can’t tolerate statins tolerate these well. Leqvio an every 6 month shot also works, but I have yet to find a drug plan to allow its use. Patients come
In all shapes and sizes, our treatments need to be more flexible.
Combination therapy with injectables like Repatha and Praluent with, or without a statin is becoming more common. Stroke and heart patient had total cholesterol over 450, got to goal on Repatha and Lipitor.
New and needed discussions are about the 50% of patients who have events with normal lipids. The role of inflammation starts to grow with the new guidelines.
Lipoprotein a, is a genetic marker for really grumpy vascular disease. We all need this test once in our lives. Currently, I am tracking down patients old labs to put on Problem lists to remind me who is lucky, and who isn’t.
Apolipoprotein B. A true marker of how lipid get laid down in our arteries is new. I try to get this number down below 60, when able. Below 90 confers some protection.
Blood Pressure. Now trying to get to 120/70-80
mmHg. Really hard to do when everyone was used to 140/90. Lower is better.
Lipid Panel. Still important. The new thing is calculating TG/HDL ratio. Triglycerides to HDL ratio, when less than 2, indicates low Insulin Resistance. IR-insulin resistance is the BIG driver of vascular damage. It also is big in cancer and dementia research.
Myeloperoxidase and HS-CRP. Two inflammation markers made in the blood vessel walls. The higher the score, the more acute risk of an event (stroke or heart attack).
Coronary Artery Calcium Score. A CT scan of the heart. More calcium, usually more artery blockages. Helps guide doctors to recommend more intense treatment. A few of my patients have ended up getting heart catheterization,
and stents due to this. Big save for them! Mine was 79 last year. 26 years of trusting stains, kept me from Dad’s fate, heart attack #1 at 48.
Homocysteine. A metabolic marker for heart disease and metabolic syndrome. Treating this lab below 9 is huge on preventing stroke, and heart attack. Some of my worst patients with bypasses found out late, that this test was over 15 mg/dl.
It is best treated with a vitamin supplement.
At the end of the day, the more abnormal tests you have, the more help to prevent vascular disease (heart and brain). The more risk factors you have the more to want to work with your doctor and nutritionist to get to goal. Risk factor wise, male s*x, being over 50, in poor shape, and smoking are still the ones that get addresses first. Obviously age marches on, and s*x assigned at birth still drives male heart disease. These are not modifiable. This all added for completeness.
We are back to testing for all of these with annual exams again. These labs also help us stratify risk for Alzheimer’s dementia.
Bonus fact. MDVIP marched out testing for p-Tau a marker for Alzheimer’s. Big Pharma is excited about new infusion therapies. So far, all my patients do not qualify for risk of stroke, or markers for bad outcomes. P-Tau should become more helpful going forward. I still recommend people seriously consider doing the Montreal Cognitive Battery annually. This test, in the public domain catches decline earlier than testing I was taught in training.
Hope this will help some of you
Thanks,
Dr. H