03/20/2026
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Luteolin is a flavonoid found in small amounts in several herbs and vegetables. Plants produce flavonoids, such as luteolin, as a cellular defense against pathogens or UV radiation. Many of these plant molecules also bring health benefits to us when we consume them.[PMC2615542]
Luteolin as an antihistamine and mast cell stabilizer:
Research shows that luteolin can act as a mast cell stabilizer and reduce histamine release.[PMC2597265] This may benefit anyone dealing with mast cell activation syndrome (MCAS) or histamine intolerance. Several mast cell researchers and clinicians recommend luteolin for preventing mast cell degranulation.
Brain Fog in MCAS: The ‘brain fog’ term applies to the inability to think clearly or concentrate. According to some researchers, inflammation along with histamine release causes brain fog in people with mast cell activation disorders. The researchers believe that luteolin can help with brain fog, citing studies that show it can improve focus in children with autism.[doi: 10.3389/fnins.2015.00225].
Luteolin as an anti-inflammatory:
Research also shows that luteolin may reduce or prevent chronic inflammation.
In cell studies, luteolin inhibits TNF-alpha and IL-6 released via suppressing NF-κB.[PMC2615542] TNF-alpha and IL-6 are linked to many chronic diseases caused by elevated inflammatory cytokines.
In other research, luteolin reduces IL-6 (interleukin 6), an inflammatory cytokine produced in response to bacterial infections.[PMC2396685]
In microglial cells, luteolin and another flavonoid, apigenin, suppress IL-31 and IL-33.[PMC7146493] IL-31 is an inflammatory cytokine produced by activated T lymphocytes, and it plays a role in chronic inflammatory diseases.
Decreasing oxidative stress: All in all, the research shows luteolin as a specific anti-inflammatory to target elevated TNF, IL-6, IL-31, and IL-33. Through protecting against inflammatory cytokine overproduction, luteolin protects against oxidative stress in cells.[PMC4664957]
Decreasing lung inflammation: Through decreasing oxidative stress and inflammation, luteolin has therapeutic effects on COPD, ARDS, pulmonary fibrosis, and asthma.[PMC11861102]
Luteolin-rich foods:
Parsley, carrots, artichokes, celery, thyme, chamomile tea, olive oil, oranges, green peppers, and oregano contain the flavone luteolin.
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This is just a short excerpt from my in-depth article on Luteolin. Here is the link to my full article: www.geneticlifehacks.com/luteolin-benefits-anti-inflammatory-and-neuroprotective/
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