02/21/2026
The 15% Difference: Why Your Generic Thyroid Meds Might Be Fluctuating 📉💊
Did you know the FDA allows a "leeway" in the potency of your thyroid medication?
In this clip, Dr. Jonathan Leffert breaks down a critical detail: a 100mcg dose of generic Levothyroxine from "Manufacturer A" can be up to 15% different in potency compared to "Manufacturer B" or a brand-name like Synthroid.
For a medication with a Narrow Therapeutic Index, that small percentage can be the difference between feeling great and falling back into brain fog or fatigue.
What you need to know:
👉The Pharmacy Factor: Pharmacies often switch generic manufacturers based on stock. You might be getting a different "version" of your dose without even knowing it.
👉Consistency is Key: It’s not that generics are "bad"—it’s that switching causes the issue. If you use a generic, try to stay with the same manufacturer every month.
👉The 6–8 Week Rule: If you do switch from brand-name to generic (or between different generics), make sure you get retested in 6 to 8 weeks to ensure your levels are still stable.
Don't let a manufacturing switch disrupt your health trajectory. Stay consistent, stay informed, and always advocate for your labs.
📍 Expert Endocrine Care | Dallas, TX
🔗 Learn more about optimizing your thyroid: ntendocenter.com/rfa