02/07/2026
Read research results
🚨 The Media Calls RFK Jr. "Crazy" on Keto and Schizophrenia—But the Science Says Otherwise
Major outlets such as The New York Times recently described Health Secretary Robert F. Kennedy Jr.'s suggestion that ketogenic or grain-free diets could help, or even "cure," schizophrenia as "unfounded."
Coverage framed it as an extreme claim, with headlines noting that he "vastly overstates preliminary research" and experts labeling it "misleading."
However, a detailed review of more than 75 years of peer-reviewed literature paints a markedly different picture.
Rather than being baseless, RFK Jr.'s comments align with historical epidemiological patterns, double-blind controlled trials, documented cases of full remission, and well-described biological mechanisms—much of which received little to no mention in the critical reporting.
🔍 Key evidence includes:
📄 Historical and Epidemiological Findings
• 1966 – Dohan (American Journal of Clinical Nutrition): During World War II, reduced wheat and rye consumption in five countries was associated with significant declines in first hospital admissions for schizophrenia. Admissions increased again when grain intake returned to pre-war levels.
• 1984 – Dohan et al. (Biological Psychiatry): In traditional grain-free societies (Papua New Guinea, Solomon Islands, Micronesia), chronic schizophrenia was extremely rare, with only 2 cases observed among more than 65,000 people. Rates rose to levels comparable to Western populations after these societies adopted grain-heavy diets.
• 1976 – Singh and Kay (Science): In a double-blind study, wheat gluten challenge in patients maintained on a grain-free and milk-free diet reversed clinical improvements. Symptoms improved when gluten was removed and worsened upon rechallenge.
📊 Modern Clinical Trials and Case Studies
• 2019 – Kelly et al. (Journal of Psychiatry and Neuroscience): Double-blind pilot randomized controlled trial (N=16) in schizophrenia patients with elevated anti-gliadin IgG antibodies. A gluten-free diet led to improvements in psychiatric symptoms, gastrointestinal symptoms, and reduced levels of inflammatory markers (TNF-α, IL-23).
• 2025 – Kelly et al.: Larger double-blind randomized controlled trial (N=39). Gluten-free intervention produced significant reductions in negative symptoms such as anhedonia, avolition, and social withdrawal.
• 2024 – Kim et al. (Schizophrenia Research): Re-analysis of the 2019 pilot data showed that gluten removal decreased oxidative stress, with reductions correlating to improvements in symptoms and inflammation.
• 2017 and 2019 – Palmer et al. (Harvard/McLean Hospital, Schizophrenia Research): Case reports of treatment-resistant schizophrenia and schizoaffective disorder patients achieving complete remission on a ketogenic diet. Symptoms recurred after discontinuing the diet and resolved again upon resumption. Some patients discontinued antipsychotic medications entirely and remained stable long-term (one case symptom-free since 1993).
• 2024 – Sethi et al. (Stanford, Psychiatry Research): 4-month single-arm pilot trial (N=21) in patients with schizophrenia or bipolar disorder and metabolic comorbidities. The schizophrenia subgroup showed approximately 32% reduction in Brief Psychiatric Rating Scale scores, with 79% achieving clinically meaningful improvement. Additional benefits included roughly 12% weight loss, improved metabolic markers, sleep, and quality of life.
🔬Biological Mechanisms
• Anti-gliadin IgG antibodies (present in approximately 25–30% of schizophrenia cases) cross-react with neuronal proteins such as synapsin I.
• Wheat germ agglutinin can cross the blood-brain barrier and promote neuroinflammation.
• Gluten-derived exorphins interfere with opioid receptor signaling in the brain.
• Certain wheat components may contribute to excitotoxicity and metabolic dysfunction in susceptible individuals.
Schizophrenia carries an enormous burden, costing the United States approximately $367 billion annually, with substantially elevated su***de risk and a life expectancy reduced by 15–20 years.
Standard treatments leave many patients, particularly those who are treatment-resistant, with limited options.
Yet dietary interventions with promising evidence have received comparatively little attention or research funding.
Instead of dismissing RFK Jr.'s statements as unfounded, the reporting could have included direct input from leading researchers in the field, such as Chris Palmer (Harvard), Shebani Sethi (Stanford), and Deanna Kelly (University of Maryland).
The evidence is substantial and merits serious, unbiased consideration.
🔗 Read the full article from Sayer Ji here: https://sayerji.substack.com/p/unfounded-rfk-jrs-grain-free-schizophrenia