08/09/2020
COVID 19 How can I prevent getting Infected with the Novel Coronavirus?
Much has been written about how to prevent infection with SARS-CoV-2, the causal agent of COVID19. I get asked on an almost daily basis things one might do to prevent infection.
At the risk of being obvious, the most important thing that any of us can do is stay away from infected people. At this writing, the rate of positive tests in Kentucky is > 6% and the number of cases is increasing at a significant rate. Areas that we thought were safe have shown the emergence of increased cases. So if you have the opportunity to stay at home and away from others (especially if you are > 65, obese, have diabetes, COPD or other lung disease, hypertension or are immunocompromised) please do it.
Unfortunately, many of us have to be exposed to others in the public and can’t always prevent contact with people around us. Masks have turned out to be remarkably more effective than originally thought so wear a mask when in public around others and keep a social distance if at all possible(>6 feet). Avoid poorly ventilated areas and staying in the proximity of others with unknown COVID status for more than 10 minutes. Wash your hands frequently and don’t contact surfaces that are likely to have been recently touched by other individuals unless you decontaminate your hands before any contact with other parts of your body-especially your face.
What about medications or supplements to prevent infection? It would be great if we could find a medication or supplement that would prevent COVID19. Unfortunately the science on this issue has gotten confused with politics and we are mired in contentious unscientific discussions about medications. Perhaps the most confusing is hydroxychloroquine (HDQ). There have been many anecdotal and uncontrolled reports of great benefit for this medication. Some have latched on to these preliminary reports and have hoped that this medication would be a panacea. There are still multiple trials ongoing using hydroxychloroquine, but the initial reports from randomized controlled trials, which are the gold standard for proof in medicine, have thus far not been favorable. In a double-blind trial, 821 individuals were randomly assigned to hydroxychloroquine or placebo folate tablets within four days of a household or occupational exposure to SARS-CoV-2, which was defined as contact within six feet for more than 10 minutes without an eye shield; most were also not wearing a medical mask. HDQ did not reduce the rate of the combined outcome of polymerase chain reaction (PCR)-confirmed COVID-19 or consistent symptoms within 14 days (11.8 versus 14.3 percent with placebo, difference -2.4 percentage points, 95% CI -7.0 to 2.2); there were also no differences in the separate rates of PCR-confirmed or presumed cases. Side effects were reported in 40.1 percent of hydroxychloroquine-treated versus 16.8 percent of placebo-treated subjects. Loss to follow-up in about 11 percent of cases, a greater rate of treatment discontinuation in the HDQ group, and use of self-reported symptoms as a proxy for incident COVID-19, reduce confidence in the findings; nevertheless, the study did not demonstrate a role for hydroxychloroquine for prevention of COVID-19.
The other RCTs involved treatment at various times during the illness and with mild, moderate and severe disease. None of these studies were favorable for hydroxychloroquine so the best current science is to not take HDQ to prevent or treat COVID19. Does this mean that a future RCT is unlikely to show a benefit for HDQ? I don’t think so. I wouldn’t be surprised if a benefit existed in a specific subset of people. We just don’t know the group that would benefit and my suggestion would be to wait for the science to support a use based on proper trials and not anecdote.
Other considerations are zinc, azithromycin, multivitamins, chiropractic and almost any “immune booster”. Maybe one or more of these interventions will prove helpful, but my suggestion would be to listen to the medical community. I believe medical scientists want desperately to help all of us get through this pandemic. Because of the extremely high stakes and lack of definitive answers, the opportunity for misinformation both well intentioned and nefarious is very great. So when someone touts a treatment or preventive for COVID19 please talk to a healthcare provider you trust that can help make sense of this very confusing topic.
In summary, distance yourselves from others, wear a mask when in public, wash your hands and for now don’t depend on a medication to protect you.
I will be the first to admit that I do not have all the answers about COVID19 (and most other diseases), but I do have experience interpreting medical information and trying to apply an evidenced based approach to interpreting the data. I have enjoyed the evolution of our understanding of this unique new virus from an educational standpoint; I am just so sorry that the consequences of infection can be so very dire. My office is open during these trying times and we remain ready to help.
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
AU
Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH
N Engl J Med. 2020