03/24/2025
PROTIENS INVOLVED IN JOINT PAIN:
Cytokines, Disintegrins, and Proteases: These proteins are involved in inflammation and can cause joint pain and cartilage erosion.
TNF-alpha (Tumor Necrosis Factor-alpha): This is a key inflammatory protein that drives rheumatoid arthritis.
Interleukin-1 beta (IL-1 beta): A cytokine protein that drives inflammation in rheumatoid arthritis.
SAA1 protein: An inflammatory protein found in the serum and synovial fluid of adults with KOA (knee osteoarthritis).
Cadherins: A family of proteins that help cells stick together and play a role in tissue structure and organization, with a specific cadherin (cadherin-11) implicated in inflammatory arthritis.
Casein: A protein found in dairy that can trigger joint pain and inflammation in some individuals.
Gluten: A protein found in wheat, rye, and barley that can cause joint pain in individuals with celiac disease or gluten sensitivity.
Proteins that Alleviate Joint Pain:
Alpha-2-macroglobulin (A*M): A naturally occurring plasma glycoprotein that combats harmful chemicals, proteins, and enzymes, protects tissue and cartilage, and helps alleviate joint pain.
Adseverin: A protein found in healthy cartilage cells that regulates the amount of filamentous (F) actin, which acts like a shield against stresses on cartilage cells.
Other Factors:
Inflammatory Foods: Certain foods, like those high in saturated fat, can trigger inflammation and worsen joint pain.
Dietary Supplements: Some dietary supplements, like collagen, may help with joint pain.
Underlying Conditions: Joint pain can be a symptom of various conditions, including osteoarthritis, rheumatoid arthritis, and celiac disease.
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