02/09/2026
Do you have questions about which supplements you should be taking? Ask Dr Sean at your next appointment
To get discounts off the type 2 collagen capsules and chocolate multicollagen powder that I take create an account here https://us.fullscript.com/protocols/ddinicolantonio-general-health. Autofill saves 15% and my Fullscript accepts HSA/FSA.
If you want to learn more about this topic, check out my book The Collagen Cure https://rb.gy/3thldn
Collagen supplementation plus regular training shows improvements in musculoskeletal outcomes.
A 2024 systematic review/meta‑analysis found that when collagen peptides were taken *over weeks alongside training*, statistically significant improvements occurred in:
•fat‑free mass
•tendon morphology
•muscle architecture
•maximal strength
•recovery after muscle damage
pubmed.ncbi.nlm.nih.gov/39060741/
Showing beneficial structural adaptations beyond what exercise alone achieves.
Collagen metabolism and tissue remodeling are slow processes.
Muscle and tendon proteins turn over over days to weeks, not minutes.
Many classic protein synthesis studies aren’t designed to capture the long‑term extracellular matrix adaptations relevant for tendons, ligaments, or skin.
Thus:
- Measuring short‑term collagen synthesis does NOT reflect cumulative remodeling benefits.
- Collagen peptides still alter extracellular matrix turnover, even without spikes in synthesis rate.
Multiple reviews show that collagen peptides:
- Improve joint function and reduce pain in people with degenerative joint conditions. pubmed.ncbi.nlm.nih.gov/34491424/
- Enhance recovery from tendon or connective tissue injury when combined with rehabilitation. pubmed.ncbi.nlm.nih.gov/34491424/
These are real world functional outcomes that matter more than just short‑term collagen synthesis numbers.
