02/05/2026
functional medicine–style, systems-based protocol for a 24-year-old male with GERD, asthma, ulcerative colitis (UC), and a true dairy allergy, currently taking Symbicort, Zyrtec, Lexapro, and Flonase.
The goal is to quiet immune activation, heal gut barrier integrity, reduce reflux triggers, and lower airway inflammation—without interfering with current medications.
Core Root-Cause Framework
This clinical picture usually overlaps four interconnected drivers:
Gut–lung axis dysregulation (UC + asthma + GERD strongly correlate)
Mucosal immune overactivation (Th2 + Th17 skewing)
Impaired barrier integrity (leaky gut → reflux → airway irritation)
Histamine & mast-cell reactivity (allergy, asthma, reflux symptoms)
The protocol below addresses each layer.
1. Diet Strategy (Non-Negotiable Foundation)
Eliminate (strict)
All dairy (true allergy → immune activation)
Gluten (strong UC + GERD trigger even without celiac)
Ultra-processed foods
Seed oils (soy, corn, canola)
Carbonated drinks, alcohol, chocolate, mint, tomato sauces (GERD triggers)
Emphasize
Protein:
Wild fish, organic poultry, grass-fed beef, eggs (if tolerated)
Carbs (low-fermentation focus):
White rice, sweet potatoes, winter squash, ripe bananas
Fats:
Extra-virgin olive oil, avocado, coconut oil
Vegetables (well-cooked):
Zucchini, carrots, spinach, peeled cucumber
UC-specific guidance
During flares → low-residue, low-FODMAP hybrid
During remission → gradual fiber reintroduction (see Nourish & Flourish below)
2. Supplement Protocol
(Designs for Health, Pure Encapsulations, Nourish & Flourish only)
A. Gut Healing & UC Support
Designs for Health GI Revive Powder
1 scoop daily away from meals
Supports mucosal repair, tight junctions, and epithelial regeneration
Pure Encapsulations L-Glutamine Powder
5 g twice daily
Primary fuel for enterocytes; supports UC remission
Pure Encapsulations Zinc Carnosine
75 mg daily
Improves gut barrier integrity and reduces reflux symptoms
B. Inflammation & Immune Modulation
Designs for Health Curcum-EVAIL
1 softgel twice daily with meals
Well-studied for UC remission and systemic inflammation
Pure Encapsulations EPA/DHA Essentials
2–3 g combined EPA/DHA daily
Reduces Th17-driven inflammation (UC + asthma)
C. GERD Support (Without Acid Suppression)
Designs for Health DGL Synergy
Chew 1 tablet before meals
Protects esophageal and gastric mucosa
Pure Encapsulations Ginger Extract
500 mg with meals
Enhances gastric emptying (reduces reflux)
D. Histamine & Airway Support
Pure Encapsulations Quercetin
500 mg twice daily
Stabilizes mast cells; supports asthma and allergies
Designs for Health HistaEze
2 capsules daily
Supports histamine metabolism without sedation
E. Microbiome Support (Carefully Selected)
Designs for Health ProbioMed 100
1 capsule daily
Evidence-based strains for UC remission and barrier repair
(Avoid spore-based probiotics initially)
F. Nourish & Flourish (Strategic Use)
Nourish & Flourish Polyphenol Shake
½ scoop daily, blended with water or almond milk
Polyphenols support:
Tight junction integrity
NF-κB downregulation
Microbiome diversity
(Avoid during active UC flares; reintroduce during stabilization phase)
3. Exercise & Breathing (Gut–Lung Axis)
Exercise (anti-inflammatory)
Zone 2 cardio: 30–45 min, 4x/week
(brisk walking, cycling)
Resistance training: 2–3x/week
Focus on compound movements
Avoid high-intensity intervals during flares
Breathing (critical for asthma + GERD)
Nasal breathing only
Diaphragmatic breathing after meals (5–10 min)
Buteyko-style breath control (reduces reflux-triggered bronchospasm)
4. Lifestyle Levers That Matter
No food within 3 hours of bedtime
Elevate head of bed (GERD + asthma overlap)
Chew food thoroughly (reduces reflux + gas)
Avoid lying flat post-meals
5. Advanced Diagnostics (High-Value)
Gut & Immune
Comprehensive stool test
(calprotectin, SIgA, dysbiosis, butyrate)
Zonulin or intestinal permeability markers
Food immune reactivity panel (IgG/IgA—not IgE)
Inflammation
hs-CRP
ESR
Omega-3 index
Nutrient Status
Vitamin D
Zinc
Magnesium
B12 / folate
Respiratory-Linked Triggers
Total IgE
Eosinophils
Consider SIBO breath test if bloating/reflux persists
Medication Compatibility Notes
No known adverse interactions with Symbicort, Zyrtec, Lexapro, or Flonase
Curcumin and omega-3s may reduce long-term steroid dependence under physician guidance
Do not discontinue prescribed meds without medical supervision
Expected Timeline
2–4 weeks: Reduced reflux, improved stool consistency, less bloating
6–8 weeks: Fewer asthma flares, improved energy
12+ weeks: Improved UC stability and immune tolerance