City of Hope

City of Hope City of Hope is a National Cancer Institute-designated comprehensive cancer center.
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Giving Tuesday is Dec. 2 — but you don’t have to wait to make an impact. Early gifts help fuel leading-edge research and...
12/01/2025

Giving Tuesday is Dec. 2 — but you don’t have to wait to make an impact. Early gifts help fuel leading-edge research and compassionate care for patients who need hope today. 💛

Make a gift here: https://bit.ly/4paFE6u

11/29/2025

When Sara Glenn was diagnosed with breast cancer at 38, she soon realized it was just the beginning of her journey. Genetic testing revealed that she and her family have Li-Fraumeni syndrome (LFS) — an inherited condition caused by a TP53 gene mutation that dramatically increases the risk for many types of cancer, including breast, bone, brain, and blood cancers.

The impact of this diagnosis deepened when Sara learned that her father, who has been battling multiple myeloma for 17 years, and both of her young daughters also carry the same mutation. Facing her own diagnosis was difficult enough, but discovering that her father and children share the same inherited risk brought a new level of heartbreak, as Li-Fraumeni syndrome now affects every generation of her family.

For families like Sara’s, knowledge truly is power. Ongoing care and vigilance are essential, and genetic testing helps families understand their risks and take steps to protect their future. If you have a family history of cancer, ask your doctor about genetic testing. It’s an important step toward early detection and peace of mind. City of Hope is helping Sara’s family navigate this journey together.

City of Hope researchers are uncovering how the trillions of microbes in your gut can influence cancer treatments and re...
11/28/2025

City of Hope researchers are uncovering how the trillions of microbes in your gut can influence cancer treatments and recovery. Disruptions to this delicate balance — often caused by antibiotics or transplants — can lead to complications.

That’s why City of Hope's Microbiome Program, led by Dr. Robert R. Jenq, is exploring ways to protect and restore gut health through diet, probiotics, and even microbiome transplants.

The goal? Safer treatments, fewer side effects, and better outcomes for patients.

Learn more: https://bit.ly/43YK9sl

11/27/2025

This Thanksgiving, we are deeply grateful for the trust and support of our patients and families, and for the stories of hope and resilience that inspire us every day.

We'd love to hear from you, too. What message of hope or gratitude would you share?

Tell us in the comments or call our at 626-218-4056.

From our City of Hope family to yours, Happy Thanksgiving!

Wishing our City of Hope patients, caregivers, families, and staff a holiday season filled with hope, warmth and joy. 💙
11/26/2025

Wishing our City of Hope patients, caregivers, families, and staff a holiday season filled with hope, warmth and joy. 💙

11/26/2025

The grand opening celebration of Orange County’s only cancer specialty hospital marked a significant milestone in the fulfillment of our promise to the 3.2 million people who call Orange County home. To the generations of people who may come through our doors frightened and in need of hope: You will find it here. This is a place of healing powered by scientific breakthroughs and compassion. It marks a new chapter for our community. 💙

🔗 : https://bit.ly/4lvtxQ3

11/26/2025

In the latest episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal welcomes Dr. Tanya Dorff, professor in the Department of Medical Oncology & Therapeutics Research and section chief of the Genitourinary Disease Program at City of Hope.

They dive into Dr. Dorff’s pioneering work in immunotherapy for prostate cancer - from the challenges of moving treatments from bench to bedside, to the importance of collaborative team-science, and the role of deep biological correlates in informing future studies.

Beyond her clinical and research achievements, Dr. Dorff reflects on mentorship, work-life balance, and the importance of supporting diversity in academic medicine. She shares how creative pursuits help her recharge and offers advice for aspiring oncologists to pursue their passions and embrace bold leaps at the edge of breakthrough.

Listen and subscribe wherever you get your podcasts.

YouTube: https://bit.ly/3M0bK6l
Apple Podcasts: https://apple.co/4opL3Wd
Spotify: https://bit.ly/43Us26W

Sidney Raskind’s world turned upside down in 2024. After he and his wife, Kelsie, lost their unborn daughter to a rare b...
11/26/2025

Sidney Raskind’s world turned upside down in 2024. After he and his wife, Kelsie, lost their unborn daughter to a rare birth defect, genetic testing revealed their daughter had a CTNNA1 gene deletion. That discovery led Sidney to get tested himself—and he learned he carried the same mutation, putting him at high risk for diffuse gastric cancer.

Sidney didn’t have symptoms, but acting on advice from a genetic counselor, he went to City of Hope for an endoscopy. The results were life-changing: early-stage diffuse gastric cancer. “It all leads back to losing my daughter,” Sidney shared. “Because of the gene deletion found in her DNA, I was able to find out I had cancer and do something about it.”

Sidney’s care team at City of Hope included experts in gastric cancer genetics and robotic surgery. After intense discussions, Sidney underwent a total gastrectomy in July 2025, performed by Dr. Yanghee Woo using a cutting-edge robotic approach. The surgery removed his stomach and reconnected his esophagus to his small intestine, allowing him to recover quickly and learn new ways to eat and drink.

Five months after surgery, Sidney is cancer-free and feeling good. He’s adapted to life without a stomach, takes daily supplements, and continues to share his journey with millions of followers on TikTok, Instagram, and YouTube.

Sidney has helped raise $75,000 for gastric cancer research, donating a significant portion to City of Hope. He encourages others to learn their family history and consider genetic testing, especially if there’s a history of cancer.

Read Sidney's story: https://bit.ly/4rkjjFb

She was 35. Healthy. Never smoked. Then came Stage 4 lung cancer.Tabitha Paccione’s persistent cough and other symptoms ...
11/25/2025

She was 35. Healthy. Never smoked. Then came Stage 4 lung cancer.

Tabitha Paccione’s persistent cough and other symptoms were first misdiagnosed as bronchitis and allergies, delaying her diagnosis.

Under the care of Dr. Ravi Salgia at City of Hope, genetic testing revealed an ALK+ mutation, and Tabitha began a personalized treatment plan with targeted ALK inhibitors.

Today, she’s in remission and advocates for lung cancer awareness and research funding — reminding us that this disease can affect anyone and that early detection and targeted treatments save lives.

Read Tabitha's story: https://bit.ly/4rkWy3N

11/24/2025

Thank you to Governor Gavin Newsom for supporting our work to bring our advanced cancer treatment and research breakthroughs closer to home for more people who need us.

With the Dec. 1 opening of Orange County’s only cancer specialty hospital in Irvine, patients will have access to the full continuum of advanced cancer care on one academic campus built for the single purpose of saving lives. We’re committed to improving the health of people in California, across the country and around the world.

🔗 : https://bit.ly/4lvtxQ3

Alisa Secaida didn’t fit the profile for lung cancer. At 35, she was a healthy mom of two, a non-smoker, with no family ...
11/18/2025

Alisa Secaida didn’t fit the profile for lung cancer. At 35, she was a healthy mom of two, a non-smoker, with no family history of lung cancer. When her symptoms were dismissed, she refused to give up—and that determination changed everything.

Her persistence led to a CT scan, then a PET scan, and finally the words she never expected: stage 4B lung cancer, with a lesion on her brain.

At City of Hope, Alisa found a team who listened. Her treatment began with chemotherapy and immunotherapy, bringing her to a milestone of no evidence of disease. When cancer returned, genetic testing revealed her tumor was ALK-positive—a rare marker that opened the door to targeted therapy.

Still, Alisa wanted more certainty. She advocated for surgery, and earlier this year, her City of Hope team scheduled a procedure to remove her upper left lung lobe and lymph nodes—confirming her instincts were right. Following surgery, Alisa completed radiation to target the remaining cancer cells.

Through every challenge, Alisa says one thing made a difference: “City of Hope gets it.” Now, she’s sharing her story to inspire others: push for second opinions, explore every option, and advocate for your health.

Read Alisa’s full story: https://bit.ly/43NJytQ

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1500 Duarte Road
Duarte, CA
91010

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Our Story

The City of Hope story began in 1913, when a group of volunteers, spurred by compassion to help those afflicted with tuberculosis, established the Jewish Consumptive Relief Association (JCRA) and raised money to start a free, nonsectarian tuberculosis sanatorium.

After several fundraisers, the JCRA put a down payment on 10 acres of sun-soaked land in Duarte, where they would establish the Los Angeles Sanatorium a year later. The original sanatorium consisted of two canvas cottages. So was launched a century-long journey that would place City of Hope at the forefront of the nation’s leading medical and research institutions.

By the mid-1940s, thanks to the discovery of antibiotics, tuberculosis was on the decline in the U.S. However, City of Hope rose to the next medical challenge, tackling the catastrophic disease of cancer — and later on, diabetes and HIV/AIDS — while reaffirming its humanitarian vision that “health is a human right.”

In the spirit of that vision, Samuel H. Golter, one of City of Hope’s early leaders, coined the phrase, “There is no profit in curing the body if, in the process, we destroy the soul.” Those words became City of Hope’s credo.