02/09/2026
So many people are asking for the pill form of Semaglutide. THE PILL IS A WASTE OF YOUR MONEY AND TIME! And here’s why:
Yesterday, Hims announced what it is calling an oral, compounded “semaglutide pill” and is marketing it with a low starting price.
This is where the public gets misled. Oral semaglutide is not just “semaglutide in a pill.”
The FDA approved oral Wegovy pill works because of a very specific SNAC formulation strategy that helps a peptide survive the stomach environment and get absorbed through the stomach lining. MOST of the compounded Semaglutide pills DO NOT contain the SNAC formulation. Even the very few that do, absorption is extremely low. We are talking roughly 1 to 2% bioavailability on a good day, with strict instructions (empty stomach, small sip of water, and waiting 30 min before eating).
Also, compounded knockoffs are not held to the same FDA standards for purity, potency, dose consistency, and proven clinical outcomes, and that applies to both pills and injectables.
So when a company sells a compounded “oral semaglutide” and markets it like it is a practical alternative to an FDA approved product, patients are being set up for a bait and switch:
- They think they are getting “Wegovy in pill form.”
- In reality, they are getting an unapproved product that has not been held to the same standards for formulation, manufacturing, or outcomes.
- And if the absorption is inconsistent or negligible, patients are paying for something that may not even have a realistic chance of delivering the intended dose.
This is exactly why FDA approval matters. It is not a technicality. It is the difference between a tested product with known pharmacology versus a potential marketing scam.
The FDA Commissioner commented last night about swift action against illegal copycat drugs and misleading marketing. I hope the FDA follows through, because this gray market of knockoff compounds is dangerous, unproven, and increasingly misleading.
Patients deserve transparency, real medications, and products that are actually tested.
(Not my article, but he hit the nail on the head!)