EpiCypher Inc.

12/24/2025

As we wrap up 2025, we’re reflecting on all the progress made in chromatin and epigenetics research.
This holiday season, we’re grateful to be part of such a dedicated scientific community.
🎁 Please note: EpiCypher will be closed from December 25 through January 1 and will reopen on January 2.
Wishing you a season of rest and renewal!

12/22/2025

Understanding a drug’s mechanism of action is critical for streamlining development and improving clinical success. Dave Lahr, PhD, shares how Foghorn Therapeutics uses EpiCypher's CUT&RUN Services to uncover drug MOA and accelerate development.

Read more: https://www.epicypher.com/resources/blog/exploring-drug-mechanism-of-action-with-cutrun-services-qa-with-foghorn-therapeutics/

12/18/2025

Fiber-seq: one giant leap for sequencing 🪐

What started as a quiet innovation has become a transformative way to study gene regulation along individual DNA molecules. Fiber-seq’s rapid enzymatic labeling combined with long-read sequencing delivers unprecedented multiomic detail — open chromatin, native 5mC, nucleosome positioning, TF footprints, structural variants, and haplotypes — all in a single experiment.

A new FierceBiotech whitepaper traces how Fiber-seq emerged, why adoption is accelerating, and the breakthroughs researchers are already uncovering with this approach.

📄 Read the whitepaper: https://fb-resources.fiercebiotech.com/free/w_defa9801/?pk=LS-WP-EpiCypher-112525-listing

12/17/2025

Planning experiments around the holidays? 🧪

Our last shipping day of 2025 is Monday, Dec 22. Shipping resumes on Monday, Jan 5, 2026.

Order early to keep your research running smoothly! Need help with timelines? Just reach out—our team’s here to help before we break for the holidays. ❄️

12/17/2025

When your data quality matters, small workflow improvements can make a big difference.

That’s why we’ve introduced CUTANA™ CUT&RUN Kit Version 6 — with practical updates designed to improve reproducibility and streamline sample handling.

See what’s new in CUT&RUN Kit v6: https://www.epicypher.com/product/cutana-chic-cutrun-kit/

12/16/2025

Behind every EpiCypher innovation is a dedicated team of scientists.
Our 2025 holiday celebration was a chance to recognize the people who drive our mission and share some well-earned joy.

Wishing our community a restful, rewarding holiday season. Here's to more discoveries in 2026! 🎊

12/15/2025

Researchers face a tough choice for DNA methylation sequencing: expensive whole-genome bisulfite sequencing, or limited insights from arrays, reduced representation bisulfite sequencing (RRBS), and targeted panels. Bisulfite conversion also damages DNA, resulting in biases that can complicate data analysis.

Read our blog to learn how meCUT&RUN avoids these pitfalls to deliver high-resolution, genome-wide DNA methylation profiles: https://www.epicypher.com/resources/blog/dna-methylation-profiling-mecutrun/

12/12/2025

💡 A new Innovation Spotlight in The Scientist sheds light on how long-read sequencing is transforming the study of complex and rare genetic diseases. In this Q&A, Bryan Venters, PhD (EpiCypher’s Senior Director of Genomic Technologies), discusses the limitations of traditional assays and how multiomic, long-read approaches provide views of chromatin that short-read methods often miss. These advances are opening the door to deeper mechanistic insight into how regulatory disruptions drive disease.

📄 Read the spotlight:

Bryan Venters of EpiCypher discusses the limitations of traditional chromatin profiling assays and explains how Fiber-seq technology overcomes these challenges.

12/12/2025

Don’t miss the final Fragile Nucleosome webinar of 2025, sponsored by EpiCypher! 🎙️

📅 December 17
Join two exciting talks on transcriptional regulation:
• JB Lalanne explores developmental enhancers (and shares insights on launching a lab)
• Rebecca Berrens dives into the role of transposable elements in development

👉 Register here: https://us06web.zoom.us/webinar/register/7717655471501/WN_i4n53UTdQLO8okWVfykxJQ

12/11/2025

Missed it live? We’ve got you covered.

The full recording of our webinar with Zach Freeman, DVM, PhD (University of Michigan) and Emily A. Madden, PhD (EpiCypher) is now available to stream on-demand.

Learn how Fiber-seq and PureTarget™ work together to reveal hidden alterations in genome-engineered models, with insights and tips you can apply to your own research.

🎥 Watch the replay:
https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

12/10/2025

CUTANA™ Cloud: CUT&RUN and CUT&Tag analysis — no coding required!

CUT&RUN and CUT&Tag have transformed genomic mapping, but many researchers still face a bottleneck at the analysis stage. CUTANA™ Cloud makes bioinformatics simple, fast, and accessible, taking you from raw data to insights in just a few clicks.

☁️ Get started: https://www.epicypher.com/CUTANA-Cloud

12/08/2025

A complete view of gene regulation shouldn’t require stitching together multiple assays.

CUTANA™ Fiber-seq captures chromatin accessibility, protein footprints, DNA methylation, and genetic variants in ONE experiment—saving time, samples, and budget. With EpiCypher's Fiber-seq Services, our team guides you from experimental design to data delivery.

Tell us about your project: https://www.epicypher.com/services/cutana-fiber-seq-assay-services/