Polarean, Inc.

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Polarean, Inc.

Comprehensive Imaging of Lung Function in One Breath We are committed to making this capability available in your lab and putting it under your control.

Polarean has acquired the key assets and intellectual property for commercializing hyperpolarized gas MRI technology. By enabling leading academic institutions and industry scientists to freely pursue innovative ideas and applications we seek to unlock the extraordinary promise of this novel technology. Whether it’s basic physics, chemistry, or clinical imaging, our mission is to encourage adoption and exploration of hyperpolarized gas technology.

01/20/2026

📣 Polarean Expands Xenon MRI into Cardiopulmonary Drug Development

Polarean has reached an important milestone by expanding the platform into pharma-sponsored cardiopulmonary drug development through a multi-center U.S. study in pulmonary hypertension associated with interstitial lung disease (PH-ILD).

In collaboration with a leading cardiopulmonary pharmaceutical company and VIDA, this work leverages quantitative Xenon MRI biomarkers to directly measure treatment effects at the pulmonary capillary level, an area of lung physiology that has historically been difficult to assess with conventional tools.

🔬 Xenon MRI has the potential to support:

❇️ Early pharmacodynamic readouts in clinical studies
❇️ Differentiation between inhaled and systemic therapies based on mechanism of action
❇️ Improved patient characterization as predominantly left-heart disease (post-capillary) or right-heart disease (pre-capillary)
❇️ Greater endpoint sensitivity in cardiopulmonary clinical trials

By pairing an inhaled therapy with an inhaled imaging signal, Xenon MRI delivers a noninvasive, radiation-free approach to quantify regional functional changes in lung ventilation, gas diffusion across the interstitial membrane, pulmonary capillary blood volume, and microvascular hemodynamics, all within a short breath hold.

This expansion highlights Xenon MRI’s growing role as a powerful imaging biomarker platform for cardiopulmonary drug development, supporting precise evaluation of therapies in diseases with high unmet need.

Read the full announcement:https://polarean.com/wp-content/uploads/2026/01/Polarean-Expands-Xenon-MRI-Platform-into-Cardiopulmonary-Drug-Development_2026-01-20.pdf

Arun Jose, MD, MS, University of Cincinnati, Sudar Rajagopal, MD, PhD, Duke University, Leslie Spikes, University of Kansas Medical Center

01/14/2026

New Insights into Pediatric Lung Diseases Using

In the first of its kind exploratory study, Cincinnati Children's looked at how Xenon MRI can be used in pediatric patients with childhood interstitial and diffuse lung diseases (chILD), specifically Neuroendocrine Cell Hyperplasia of Infancy (NEHI). The results from the research study showed that Xenon MRI can effectively reveal ventilation heterogeneity and interstitial tissue abnormalities in these patients, making it a valuable diagnostic tool, especially for conditions like NEHI, where traditional imaging may fall short.

Read the paper 🔍
https://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.27410

chILD Foundation - Childrens Interstitial and Diffuse Lung Disease

Children’s Interstitial Lung Disease Foundation

01/12/2026

✨ New Peer-Reviewed Evidence: Xenon MRI Predicts Cystic Fibrosis Exacerbations ✨

A newly published American College of Chest Physicians study shows that ventilation defects can independently predict future pulmonary exacerbations in people with cystic fibrosis ( ), beyond prior clinical history and spirometry results.

The findings highlight how advanced imaging can reveal functional lung changes that conventional tests may miss—particularly in patients with mild or gradual decline.

This work reflects broader priorities across the cystic fibrosis community to advance sensitive, quantitative biomarkers that support personalized care and more efficient clinical trials.

At Polarean, our Xenon MRI platform is designed to bring precise, functional lung imaging into routine clinical practice, helping clinicians visualize physiologic details that matter for early intervention and monitoring.

Read the press release:https://polarean.com/wp-content/uploads/2026/01/Chest-Journal-Study-Demonstrates-Xenon-MRI-Predicts-CF-Exacerbations_2026-01-12.pdf

01/07/2026

✨ 2026: The Year of Xenon MRI ✨

Xenon MRI is transforming how lung function is visualized, moving beyond anatomy to reveal functional insights from a single breath-hold. By making the invisible visible, it enables sensitive detection, clear monitoring, and deep understanding of lung disease.

With growing clinical adoption, 2026 is set to be a defining year for functional lung imaging and patient care.

Learn more: xenoview.net

12/23/2025

As 2025 comes to a close, we want to thank our incredible team and partners for your dedication, creativity, and collaboration. 👏 Together, you are helping advance our mission to revolutionize pulmonary medicine through direct visualization of lung function!

This holiday season, we’re celebrating the people behind the innovation. The faces, energy, and teamwork that power Polarean and make progress possible. From everyday moments to major milestones, it’s the shared commitment that continues to move our mission forward.

Happy Holidays from all of us at Polarean! 💙

12/16/2025

🎉 Congratulations to Robby Thomen, PhD and team on receiving major funding for this exciting asthma research milestone! 🎉

We’re thrilled to see new research from the MU School of Medicine receive a $1.8-million grant from the National Institutes of Health (NIH) to advance understanding of asthma triggers and disease mechanisms.

Robby and his team are using Polarean's platform to visualize regional lung function and investigate whether airway hyperconstriction in asthma also happens in the lung's blood vessels, or vasculature. This long-standing hypothesis in asthma research has been challenging to study, and Xenon MRI offers a new way to explore functional relationships that are not accessible with conventional imaging.

This work represents an important step toward more precise, personalized approaches to asthma care and may help explain why some patients respond well to treatment while others continue to experience uncontrolled disease. We look forward to seeing how this research helps move asthma care forward!

Learn more: https://medicine.missouri.edu/news/researcher-receives-18-million-study-asthma-triggers

12/11/2025

⭐ A Comprehensive Review of Xenon MRI in Pulmonary Imaging ⭐

A recent review published in Radiology: Cardiothoracic Imaging (Radiological Society of North America (RSNA), Aug 2025) provides an in-depth overview of — from its underlying physics and acquisition methods to established clinical applications in ventilation imaging and gas-exchange imaging as an active area of research.

This review reinforces what we see every day at Polarean:

✨ Xenon MRI is a validated, mature technology offering functional insights beyond CT and spirometry.

✨ Xenon MRI can help fill critical diagnostic gaps by enabling sensitive detection of early or mild disease that may not be captured by conventional pulmonary function tests.

As adoption grows across academic centers, pharma-sponsored trials, and new indications, we’re proud to be at the forefront of this transformation in pulmonary imaging.

📖 Read the full paper here: https://doi.org/10.1148/ryct.240562

12/05/2025

A strong week for Polarean at RSNA 2025! 🌟

Our team had the opportunity to meet with both new and existing customers, connect with clinical and industry partners, and continue the important dialogue around the role of in advancing modern respiratory imaging.

Across the meeting, we saw continued interest in functional lung imaging—from clinicians seeking deeper insight into airway disease and researchers exploring gas exchange to health systems assessing how Xenon MRI can enhance patient care. Conversations throughout the week reaffirmed the growing recognition of the value our technology provides.

Thank you to everyone who visited with us at Radiological Society of North America (RSNA) 2025! 👏 We appreciate the collaboration and look forward to building on this momentum as we work to expand access, illuminate hidden disease, and improve outcomes for patients.

Learn more about us: xenoview.net

12/02/2025

It’s today! Join Polarean at the Xenon MRI Social at Radiological Society of North America (RSNA) 2025 🎉

✨ Xenon MRI Social: Connect with the Experts
🕕 6:00–8:30 PM (Open House)
📍 The TAP, Hyatt Regency McCormick Place

Stop by tonight to meet peers, connect with leaders in Xenon MRI, and learn how functional imaging is advancing care across radiology and pulmonary medicine.

🔗 Event details & RSVP: https://lp.uniqo.de/KPKBqo

And while you're at RSNA, we’d love to see you at Booth #3980 to explore what’s new in functional lung imaging.

12/01/2025

Polarean announces key milestone: XENOVIEW® 3T Coil passes Philips compatibility testing 🌟

We’re proud to share that our FDA-cleared XENOVIEW® 3T Chest Coil has successfully completed compatibility testing with Philips’ latest 3T MRI systems, marking an important step in expanding clinical access to advanced pulmonary imaging.

This milestone means the XENOVIEW 3T Chest Coil is now confirmed for integration with Philips MRI platforms, including the MR 7700 and Ingenia Elition X, beginning in early 2026.

By enabling seamless integration of Polarean’s technology across a major global installed base, this achievement brings us closer to our mission of transforming lung imaging with noninvasive, quantitative assessments of lung function that empower both clinicians and patients.

We look forward to continuing our work with partners and healthcare providers to make advanced functional lung imaging accessible worldwide.

Learn More:https://polarean.com/wp-content/uploads/2025/11/POLX-chest-coil-testing-Approved-Philips-_2025-12-01.pdf

11/26/2025

🦃 Happy Thanksgiving from all of us at Polarean!

This season, we’re grateful for our partners, collaborators, and the clinicians and researchers around the world who share our commitment to advancing lung health and transforming pulmonary imaging.

Thank you for being part of our journey. Your dedication and innovation inspire everything we do.

Wishing everyone a safe, joyful, and restorative Thanksgiving! 🍂

11/25/2025

🫁 Join Polarean at Radiological Society of North America (RSNA) 2025 — and at the Xenon MRI Social!

We’re excited to connect with the radiology community starting this weekend! Make plans to join us for an evening of networking and stop by our Booth #3980 throughout the conference.

✨ Xenon MRI Social: Network with the Experts
📅 Tuesday, Dec 2 | 🕕 6:00–8:30 PM (Open House)
📍 The TAP at Hyatt Regency McCormick Place

Meet the experts behind , connect with peers, and learn how functional lung imaging is advancing care across radiology and pulmonary medicine.

🔗 RSVP & event details: https://lp.uniqo.de/KPKBqo

We look forward to seeing you in Chicago! ✨

Address

2500 Meridian Pkwy Ste 175
Durham, NC
27713

Telephone

+19192067900

Website

http://www.polarean.com/

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