Main Street Pharmacy

Main Street Pharmacy Main Street Pharmacy is a locally owned and operated pharmacy in East Prairie, Missouri!

03/12/2026

👶 A Special Announcement from Main Street Pharmacy 👶

We will be CLOSED Friday, March 13th as our family welcomes Baby Hubbard into the world!

Thank you all for your understanding and continued support of our small, family-owned pharmacy. Moments like this remind us how grateful we are to be part of such a wonderful community. ❤️

We will reopen with normal hours after this special day.

— Main Street Pharmacy 💊

01/26/2026

❄️ Winter Update ❄️

We will be open 10:00–2:00 tomorrow.

Huge thanks to our amazing volunteer who helped clear the alley and drive-thru so we can safely serve you!

If you have an emergent medication need, please send us a message and we’ll do everything we can to get it to you.

Stay safe and warm, East Prairie ❤️

Winter Storm Coming ❄️Don’t get caught without your meds.Check your refills and plan ahead.📞 573-649-9229We’ll help you ...
01/21/2026

Winter Storm Coming ❄️

Don’t get caught without your meds.
Check your refills and plan ahead.

📞 573-649-9229
We’ll help you stay prepared.

01/06/2026

✨ Vendor Space Now Available at Main Street Pharmacy! ✨

Are you a crafter, maker, or hobbyist selling out of your home? Looking for a brick-and-mortar presence without the overhead of a full storefront?

Main Street Pharmacy is now offering vendor spaces for rent—giving local creators a place to showcase and sell their products inside an established, high-traffic business.

✔ No long-term lease
✔ No utilities or staffing costs
✔ Affordable monthly space
✔ Perfect for handmade goods, crafts, gifts, and specialty items

This is a great opportunity to grow your business, gain visibility, and reach new customers without the risk and expense of opening your own shop.

📍 Spaces are limited!

📩 Message us or stop by Main Street Pharmacy for details.

Support local. Shop local. Sell local. 🛍️

Today’s Stocking Stuffer Spotlight 🎄🧦🥃Today at Main Street Pharmacy, we’re featuring gifts dad will actually use (and lo...
12/08/2025

Today’s Stocking Stuffer Spotlight 🎄🧦🥃

Today at Main Street Pharmacy, we’re featuring gifts dad will actually use (and love):

🧵 Leather coasters – classy, durable, and perfect for his favorite chair side table

😂 Funny socks for Dad – add a little humor under the tree

🥃 Engraved whiskey glasses – a personalized touch for his nightcap

Swing by Main Street Pharmacy and grab a few to tuck in his stocking. Mix, match, and get your gifting done while our stocking stuffer sale is going on! 🎁✨

Today’s Friday Stocking Stuffer at Main Street Pharmacy 🎄Bamboo picture frames & cozy coffee mugs – the perfect pair for...
12/05/2025

Today’s Friday Stocking Stuffer at Main Street Pharmacy 🎄
Bamboo picture frames & cozy coffee mugs – the perfect pair for a thoughtful, easy gift!

✅ Great for teachers, coworkers, grandparents, and gift exchanges
✅ Mix and match frames and mugs for a personalized touch

Stop by Main Street Pharmacy today and snag a few for those stockings before they’re gone! ☕🖼️🎁

🎄 Today’s Stocking Stuffer Feature: Gifts for Dad! 🎄Looking for something he’ll actually love? We’ve got you covered!✨ L...
12/04/2025

🎄 Today’s Stocking Stuffer Feature: Gifts for Dad! 🎄

Looking for something he’ll actually love? We’ve got you covered!

✨ Leather Keychains – Durable, stylish, and perfect for everyday carry.
🧢 Hats – A great fit for any Dad on the go.
🕯️ Manley Cedar-Scented Candles – That warm, woodsy scent he’ll enjoy all season long.

Stop by Main Street Pharmacy and snag the perfect stocking stuffers to make Dad’s Christmas morning extra special! 🎅🏼🎁

✨ Today’s Stocking Stuffer at Main Street Pharmacy! ✨Give the gift of cozy winter self-care with our Nordic Wellness Vit...
12/03/2025

✨ Today’s Stocking Stuffer at Main Street Pharmacy! ✨

Give the gift of cozy winter self-care with our Nordic Wellness Vitamin C Hand Cream & Soap — the perfect little duo to brighten anyone’s holiday season!

🎄 Vitamin C Hand Cream
Keeps hands soft and hydrated all winter long with a burst of nourishing Vitamin C. A great way to beat that dry holiday weather!

🎁 Vitamin C Soap
A refreshing, clean scent with skin-loving ingredients — festive, fresh, and perfect for gifting.

These make excellent stocking stuffers, teacher gifts, or add-on treats for anyone on your Christmas list. Stop by Main Street Pharmacy and grab yours today… before Santa does! 🎅✨

12/03/2025

🎄 STOCKING STUFFER SALE at Main Street Pharmacy! 🎄

The holidays are here, and so are the deals! Now through Christmas, enjoy BUY ONE, GET ONE FREE on all gift inventory in the store. It’s the perfect time to grab affordable stocking stuffers, last-minute gifts, and customer favorites before they’re gone!

✨ Starting today, we’ll be posting a featured stocking-stuffer item every day—so keep an eye on our page for ideas and steals you won’t want to miss.

We’re clearing out inventory to make room for exciting new items coming in January… and trust us, you’ll want to stay tuned for a BIG announcement once this sale wraps up!

Stop by, shop local, and save big this holiday season at Main Street Pharmacy! 🎁

Wishing you all a safe and very Happy Thanksgiving!🦃
11/27/2025

Wishing you all a safe and very Happy Thanksgiving!🦃

Happy Veteran's Day❤
11/11/2025

Happy Veteran's Day❤

Happy Pharmacy Technician Day! 💊 Thank you for all you do! ❤️
10/21/2025

Happy Pharmacy Technician Day! 💊 Thank you for all you do! ❤️

Address

117 E Main Street
East Prairie, MO
63845

Opening Hours

Monday 8:30am - 5:30pm
Tuesday 8:30am - 5:30pm
Wednesday 8:30am - 5:30pm
Thursday 8:30am - 5:30pm
Friday 8:30am - 5:30pm

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