02/07/2026
Here are the three primary reasons methylene blue is used and discussed in complex tick-borne illness cases:
🔵 Persister / stationary-phase relevance for Borrelia (Lyme):
Research has identified methylene blue among compounds with activity against stationary-phase (persister-like) Borrelia burgdorferi in vitro. This matters because many chronic cases appear to involve forms of microbial persistence that don’t behave like an acute infection.
🔵 Bartonella relevance, including biofilm discussion:
Bartonella can be a major driver of neuropsychiatric symptoms, neuropathy, vascular-type symptoms, and profound fatigue in chronic cases. In vitro data have shown methylene blue performing strongly against stationary phase and biofilm-recovered Bartonella henselae cells, particularly in combination strategies.
🔵 Mitochondria + neurological support (energy, oxygen, brain):
One of the most clinically meaningful aspects of methylene blue, in my experience, is its ability to support patients whose primary limiting symptoms are fatigue and neurological dysfunction—brain fog, slowed cognition, neuropathic sensations, and reduced resilience. MB is often discussed in relation to supporting electron transport chain function (commonly framed around Complex IV/cytochrome oxidase activity) and oxidative metabolism. When patients feel “oxygen-starved” at the cellular level—despite normal-looking labs—this is one tool that may help.
Click to read the full article: https://restorativehealthsolutions.com/blog/lyme-disease/methylene-blue-for-lyme-disease-and-bartonella/
