04/09/2026
Why does gardening feel so good? ššøššŖ“ š§ āØ
When you dig your hands in the dirt, you may be meeting some friendly bacteria called mycobacterium vaccae (pronounced vahh - kayy). These bacteria can help your brain release more serotonin. Increased levels of serotonin can decrease depression, anxiety and stress levels. Some scientists refer to the mycobacterium vaccae as āold friendsā š„°
Gardening can also be a moderate form of exercise, which helps increase blood flow to your brain and the release of feel good neurotransmitters (such as dopamine and GABA). Being outside in nature, surrounded by the colour green and bird songs can also help you relax. šæš¦
How does this mycobacterium vaccae work to increase serotonin? Scientists have found that in mice it activates the interfascicular part of the dorsal raphe nucleus (DRI). This is the brain region where most serotonin in the brain is synthesized. The mycobacterium vaccae can increase the TPH2 (tryptophan hydroxylase) enzyme that helps convert tryptophan to serotonin!
Are you ready for gardening this spring?
Reference:
Lowry, J.H. et al. Identification of an immune-responsive mesolimbocortical serotonergic system.
Neuroscience (2007) https://doi.org/10.1016/j.neuroscience.2007.01.067