01/21/2022
This patient presented with a submacular hemorrhage and complaints of loss of central vision and metamorphopsia for 2 months in the setting of age-related macular degeneration.
Prompt treatment is critical to prevent toxicity to photoreceptor and retinal pigment epithelium cells. The subretinal fluid and hemorrhage decrease the passage of nutrients to the overlying retina in addition to the toxicity caused by the blood breakdown (hemosiderin, iron, fibrin) and mechanical damage to photoreceptors by clot shrinkage.
Treatment algorithms depend on time of presentation given visual prognosis. In our group, patients presenting within 2 weeks of symptoms are taken to surgery where we perform Pars Plana Vitrectomy, Internal Limiting Membrane Peel, Subretinal Tissue Plasminogen Activator, Subretinal Air, Gas.
Another treatment option as with this patient who presented with 2 months of symptoms is prompt intravitreal anti-VEGF therapy (aflibercept in this case). Subretinal fluid and hemorrhage completely resolved with 4 intravitreal aflibercept injections, improving his vision from 20/100 to 20/20.