11/07/2025
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Researchers at Washington University School of Medicine have discovered a potential new approach to combat age-related memory decline by enhancing the brain’s lymphatic vessels. These vessels, part of the meningeal lymphatic system, help drain waste and fluid from the brain, but their efficiency decreases with age. In older mice, rejuvenating these vessels led to significant memory improvements and reduced harmful brain inflammation, highlighting a promising strategy for cognitive health.
The study, published in Cell, demonstrates that stimulating lymphatic vessel growth restores the brain’s natural cleaning process. As the brain ages, waste accumulates and overwhelms immune cells, contributing to memory loss and diseases like Alzheimer’s. By improving fluid flow in the brain, the researchers observed better performance in memory tests, suggesting that supporting these vessels could directly impact cognitive function.
These findings open the door to therapies that target the brain’s waste-removal system rather than neurons themselves. By restoring balance to this vital “brain cleaning” network, scientists hope to slow or even reverse some effects of aging, offering a novel route for tackling neurodegenerative diseases.
📌 Source / Credit:
Da Mesquita, S., Louveau, A., et al. (2025). Functional rejuvenation of the aged brain lymphatic system improves memory in mice. Cell