11/15/2021
The newest in a long list of studies connecting a diet high in inflammatory foods with dementia--& conversely, diets high in anti-inflammatory foods--like fruits, vegetables, & legumes--with prevention. This study included 1059 individuals with a mean age of 73.
Diets with higher inflammatory potential appeared linked to increased risk for incident dementia, according to results of a population-based study published in Neurology.
“We do not well understand the mechanism via which diet may affect brain health,” Nikolaos Scarmeas, MD, PhD, of the 1st department of neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Greece, told Healio Neurology.
“It may have some influence on brain vascular health, on brain oxidative stress, on neurodegenerative changes, etc. The present study provides some evidence that diet may influence cognitive function via inflammation-related mechanisms.”
“People who were eating a more anti-inflammatory diet had lower risk for developing dementia over the course of approximately 3 years,” according lead author, Nikolaos Scarmeas. “However, we should note that the study was an observational one, not a clinical trial. Therefore, it does not prove that eating an anti-inflammatory diet prevents brain aging and dementia, it only shows an association.”
"A diet with a more anti-inflammatory content seems to be related to lower risk for developing dementia within the following 3 years," Scarmeas told MedPage Today. Available dementia treatments are not very effective, he said -- "it's quite important that we find some measures to partially prevent it."
"Diet might play a role in combating inflammation, one of the biological pathways contributing to risk for dementia and cognitive impairment later in life," he added.
Evidence suggests certain foods, nutrients, and non-nutrient food components can modulate inflammatory status acutely and chronically. Earlier prospective research looked at dietary inflammatory potential and cognitive decline only in women, not in both sexes, the researchers noted.
Scarmeas and co-authors analyzed data from 1,059 older adults in the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD), a population-based study that investigates associations between nutrition and age-related cognition in Greece. People with dementia at baseline were excluded from the analysis.