International Perfusion Association

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This pilot study evaluated how cardiopulmonary bypass (CPB), with and without hypothermic circulatory arrest (HCA), affe...
03/02/2026

This pilot study evaluated how cardiopulmonary bypass (CPB), with and without hypothermic circulatory arrest (HCA), affects red blood cell (RBC) morphology, membrane nanostructure, and mechanical properties using atomic force microscopy. In 14 cardiac surgery patients, CPB increased RBC stiffness, while CPB+HCA caused more severe morphological damage and membrane roughness.
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This pilot study evaluated how cardiopulmonary bypass (CPB), with and without hypothermic circulatory arrest (HCA), affects red blood cell (RBC) morphology, membrane nanostructure, and mechanical properties using atomic force microscopy. In 14 cardiac surgery patients, CPB increased RBC stiffness, w...

This retrospective single-center study of 475 patients with acute type A aortic dissection undergoing total arch replace...
02/28/2026

This retrospective single-center study of 475 patients with acute type A aortic dissection undergoing total arch replacement with stented elephant trunk implantation found that prolonged cardiopulmonary bypass (CPB) weaning time was independently associated with increased in-hospital mortality and postoperative stroke.

This retrospective single-center study of 475 patients with acute type A aortic dissection undergoing total arch replacement with stented elephant trunk implantation found that prolonged cardiopulmonary bypass (CPB) weaning time was independently associated with increased in-hospital mortality and p...

This study evaluates the safety and effectiveness of cardiopulmonary bypass (CPB) as hemodynamic support during combined...
02/28/2026

This study evaluates the safety and effectiveness of cardiopulmonary bypass (CPB) as hemodynamic support during combined high-risk percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR).

This study evaluates the safety and effectiveness of cardiopulmonary bypass (CPB) as hemodynamic support during combined high-risk percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). The authors demonstrate that CPB provides stable circulatory support, enablin...

This technique article describes a novel method for converting pediatric patients from veno-arterial extracorporeal memb...
02/28/2026

This technique article describes a novel method for converting pediatric patients from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) to cardiopulmonary bypass (CPB) using a single circuit with the addition of a cardiotomy reservoir. In seven patients (eight procedures), the approach preserved circulating blood volume, limited donor exposure, and maintained effective surgical support.

This technique article describes a novel method for converting pediatric patients from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) to cardiopulmonary bypass (CPB) using a single circuit with the addition of a cardiotomy reservoir. In seven patients (eight procedures), the approach pr...

This article describes how a cardiac surgery program at Massachusetts General Hospital transformed its operating room cu...
02/27/2026

This article describes how a cardiac surgery program at Massachusetts General Hospital transformed its operating room culture by leveraging the unique perfusionist-surgeon relationship.

This article describes how a cardiac surgery program at Massachusetts General Hospital transformed its operating room culture by leveraging the unique perfusionist-surgeon relationship. By promoting psychological safety, challenging hierarchical assumptions, and implementing structured guidelines, c...

This nationwide propensity-matched study of 7.5 million U.S. heart failure hospitalizations (2016–2022) found that urban...
02/27/2026

This nationwide propensity-matched study of 7.5 million U.S. heart failure hospitalizations (2016–2022) found that urban teaching hospitals had higher inpatient mortality, complication rates, length of stay, costs, and palliative care consultations compared with urban non-teaching hospitals. Despite worse in-hospital outcomes, 30- and 90-day readmission rates were similar.

This nationwide propensity-matched study of 7.5 million U.S. heart failure hospitalizations (2016–2022) found that urban teaching hospitals had higher inpatient mortality, complication rates, length of stay, costs, and palliative care consultations compared with urban non-teaching hospitals. Despi...

This systematic review and meta-analysis of 10 observational studies (5,364 patients) compared Impella and VA-ECMO for c...
02/24/2026

This systematic review and meta-analysis of 10 observational studies (5,364 patients) compared Impella and VA-ECMO for cardiogenic shock. No significant difference in short-term mortality was found (RR 0.92). However, Impella was associated with lower risks of stroke, major bleeding, and limb ischemia. Evidence certainty was very low due to confounding bias.

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This 20-year single-center study of 528 heart transplant recipients compared three preservation solutions: Celsior, HTK-...
02/23/2026

This 20-year single-center study of 528 heart transplant recipients compared three preservation solutions: Celsior, HTK-Custodiol, and St Thomas. HTK-Custodiol was associated with a significantly higher rate of severe primary graft dysfunction (10.2% vs 4.5%), but long-term survival and rejection rates were similar across groups.

This 20-year single-center study of 528 heart transplant recipients compared three preservation solutions: Celsior, HTK-Custodiol, and St Thomas. HTK-Custodiol was associated with a significantly higher rate of severe primary graft dysfunction (10.2% vs 4.5%), but long-term survival and rejection ra...

This large UNOS registry study of 8,489 DCD liver transplants (2010–2024) found that shorter donor time to death (TTD) w...
02/23/2026

This large UNOS registry study of 8,489 DCD liver transplants (2010–2024) found that shorter donor time to death (TTD) was associated with worse graft survival, while prolonged TTD did not negatively impact outcomes—even without normothermic regional perfusion (NRP). Despite this, liver utilization declined sharply after 15 minutes of TTD.

This large UNOS registry study of 8,489 DCD liver transplants (2010–2024) found that shorter donor time to death (TTD) was associated with worse graft survival, while prolonged TTD did not negatively impact outcomes—even without normothermic regional perfusion (NRP). Despite this, liver utilizat...

This single-center retrospective study evaluated 422 pulmonary fibrosis patients undergoing bilateral lung transplantati...
02/23/2026

This single-center retrospective study evaluated 422 pulmonary fibrosis patients undergoing bilateral lung transplantation between 2012 and 2025. After adopting a more liberal elective intraoperative veno-arterial ECMO strategy in 2020, the incidence of severe primary graft dysfunction (PGD grade 3 at 72 hours) significantly decreased.

This single-center retrospective study evaluated 422 pulmonary fibrosis patients undergoing bilateral lung transplantation between 2012 and 2025. After adopting a more liberal elective intraoperative veno-arterial ECMO strategy in 2020, the incidence of severe primary graft dysfunction (PGD grade 3....

In this multicentre study of 335 ECMO patients, high-resolution device and electronic health record data were integrated...
02/22/2026

In this multicentre study of 335 ECMO patients, high-resolution device and electronic health record data were integrated to develop a two-stage artificial intelligence model capable of simulating ECMO circuit behavior and patient physiological responses. The digital twin was deployed in a virtual reality platform with real-time inference.

In this multicentre study of 335 ECMO patients, high-resolution device and electronic health record data were integrated to develop a two-stage artificial intelligence model capable of simulating ECMO circuit behavior and patient physiological responses. The digital twin was deployed in a virtual re...

This retrospective cohort study of 343 reoperative cardiac surgery patients found that low indexed oxygen delivery (DO₂i...
02/21/2026

This retrospective cohort study of 343 reoperative cardiac surgery patients found that low indexed oxygen delivery (DO₂i) during cardiopulmonary bypass independently predicted in-hospital mortality and major morbidity. A median DO₂i below 289 mL/min/m² was associated with a fourfold increase in mortality risk, higher rates of acute kidney injury, cardiac complications, and prolonged ventilation.

This retrospective cohort study of 343 reoperative cardiac surgery patients found that low indexed oxygen delivery (DO₂i) during cardiopulmonary bypass independently predicted in-hospital mortality and major morbidity. A median DO₂i below 289 mL/min/m² was associated with a fourfold increase in...

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