11/18/2025
Creatine for Peri- and Postmenopausal Women: Why it Matters
If you’re in perimenopause or postmenopausal, preserving muscle is one of the most powerful things you can do for long-term health, mobility, and independence. Alongside protein and resistance training, creatine monohydrate is a well-studied supplement that can help—safely and inexpensively.
Falling estrogen is linked to accelerated losses of muscle strength and function. A 2021 systematic review and meta-analysis of randomized trials in older females found that adding creatine to resistance training produced significant gains in strength versus training alone—especially in programs lasting ≥24 weeks.
Beyond muscle, large randomized trials in postmenopausal women are exploring bone outcomes. A recent 2-year RCT tested daily creatine with supervised exercise; while the trial’s primary focus was bone health, it reinforces long-term safety and the practicality of daily dosing in this population.
Proven muscle benefits you can expect include stronger lifts and everyday function (e.g., carrying groceries, stair climbing) when creatine is paired with progressive resistance training) and possible improvements in lean mass/appendicular muscle in older women in some trials—again, most reliably when combined with training.
How much to take (dosage you can trust): Creatine monohydrate is the form with the best evidence. Two evidence-based ways to dose:
*Loading + maintenance: 20 g/day split into 4 doses for 5–7 days, then 3–5 g/day thereafter.
*No-load option: 3–6 g/day consistently; you’ll reach the same muscle saturation in ~3–4 weeks.
When to take it: timing is flexible—consistency beats timing—but many people take it with a meal or near training to minimize GI upset and potentially aid uptake.
For safety tips when taking creatine and links to research studies and references, visit my website www.elizabethstorymd.com