Mass Spectrometry and Proteomics Laboratory

Mass Spectrometry and Proteomics Laboratory Research-oriented mass spectrometry and proteomics laboratory; also available for service type of work. Director: Laszlo Prokai, PhD, DSc (Welch Chair)

Mass spectrometry and proteomic services include: MS, LC-MS, high resolution MS, tandem mass spectrometry (MS/MS, MS^n), protein identification by proteolytic digest, nano LC-MS/MS and database search, molecular weight determination, support of preclinical drug development (pharmacokinetics, drug distribution, metabolite profiling, etc.) We have three LC-MS systems and a GC-MS (all from Thermo Scientific, San Jose, CA). Software resources include the proteomics software Bioworks, Sequest, Mascot, Scaffold, DeNovoX, etc., Metabolite ID, and many more.

Our group has just published this paper in the International Journal of Molecular Sciences 😀
03/02/2021

Our group has just published this paper in the International Journal of Molecular Sciences 😀

The widely used rat uterotrophic assay to assess known and potential estrogenic compounds only considers uterine weight gain as endpoint measurement. To complement this method with an advanced technology that reveals molecular targets, we analyzed changes in protein expression using label-free quant...

Collaboration with Professor Shulaev's laboratory at UNT: Just published in the International Journal of Molecular Scien...
01/08/2021

Collaboration with Professor Shulaev's laboratory at UNT: Just published in the International Journal of Molecular Sciences

The early signaling events involved in oxidant recognition and triggering of oxidant-specific defense mechanisms to counteract oxidative stress still remain largely elusive. Our discovery driven comparative proteomics analysis revealed unique early signaling response of the yeast Saccharomyces cerev...

08/22/2020

The official YouTube Channel for Tarrant County Commissioner Roy Charles Brooks. This channel highlights his Healthy Lives Matter Initiative and it’s program...

Just ePublished ...
06/12/2020

Just ePublished ...

Carisoprodol (Soma®) is a centrally-acting skeletal-muscle relaxant frequently prescribed for treatment of acute musculoskeletal conditions. Carisopro…

The International Journal of Molecular Sciences invites submissions to its Special Issue entitled "High Resolution Mass ...
01/18/2019

The International Journal of Molecular Sciences invites submissions to its Special Issue entitled "High Resolution Mass Spectrometry in Molecular Sciences" edited by Laszlo Prokai:

International Journal of Molecular Sciences, an international, peer-reviewed Open Access journal.

Congratulations to Daniel De La Cruz and his mentor (Professor Katalin Prokai-Tatrai) on his successful defense of the t...
07/17/2018

Congratulations to Daniel De La Cruz and his mentor (Professor Katalin Prokai-Tatrai) on his successful defense of the thesis for the Master of Science degree! We are looking forward to continuation with Daniel pursuing Doctor of Philosophy (Ph.D.) in Biomedical Sciences under her tutelage in our lab.

Download for free: K. Prokai-Tatrai and L. Prokai, "17β-Estradiol as a neuroprotective agent," In: S*x Hormones in Neuro...
05/17/2018

Download for free:
K. Prokai-Tatrai and L. Prokai, "17β-Estradiol as a neuroprotective agent," In: S*x Hormones in Neurodegenerative Processes (G. Drevenšek, Ed.), InTech, Rijeka, Croatia, 2018, pp. 21-39.

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Published recently: An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of A...
03/02/2018

Published recently: An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Hormones and BehaviorVolume 98, February 2018, Pages 16-21An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's diseaseAuthor links open overlay panelAnna E.Tschiffelyab1Rosemary A.SchuhcdKatalinProkai-TatraieMary AnnOttingerb23LaszloProkaie2h...

Very proud of Dr. Prokai and his achievement in winning the ACS Doherty Award!
10/29/2017

Very proud of Dr. Prokai and his achievement in winning the ACS Doherty Award!

Award recognizes significant achievements in research, teaching, and service

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3500 Camp Bowie Boulevard
Fort Worth, TX
76107

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