02/28/2026
Another reason why its so important to have compassion for those who are grieving.
New brain research confirms prolonged grief disorder is a distinct neurological condition, not just a lingering emotional state.
For approximately five percent of bereaved individuals, the pain of loss does not fade with time, but instead manifests as prolonged grief disorder (PGD). Recent neuroimaging studies reveal that this condition is rooted in specific brain activity rather than a simple lack of resilience. In those with PGD, the brain’s reward system—specifically the nucleus accumbens—becomes "locked" onto the memory of the deceased. This creates a neurological loop of intense yearning that fails to adapt to the present, while heightened activity in the amygdala and hippocampus triggers profound distress at reminders of death. This unique neural profile makes it physically difficult for the individual to regulate emotions or find joy in new experiences.
These biological insights are critical because they distinguish PGD from other conditions like depression or PTSD. Unlike depression, PGD involves a chronic "reward-seeking" yearning for the lost loved one rather than the avoidance behaviors typically seen in trauma. Recognizing these differences allows for more precise medical interventions; for instance, while PGD typically resists traditional antidepressants, it responds effectively to grief-specific psychotherapies. By identifying high-risk brain connectivity patterns shortly after a loss, clinicians may soon be able to predict who will develop chronic symptoms and provide early, specialized support to prevent years of debilitating suffering.
source: Thomson, H. (2026). Why some people cannot move on from the death of a loved one. New Scientist.