12/29/2025
Nasolabial folds (NLFs) are a key marker of facial aging, and hyaluronic acid (HA) fillers remain a cornerstone of aesthetic correction 💉✨. This new study compares Lunaphil Ultra and Juvéderm Ultra 4 in a rigorous 24-week evaluation.
Each participant received Lunaphil Ultra in one NLF and Juvéderm Ultra 4 in the other. Researchers assessed wrinkle severity using the Wrinkle Severity Rating Scale (WSRS) and allowed touch-up injections if needed.
The results: both fillers produced similar improvements (mean WSRS change: −0.80 vs −0.81, P > .99), with comparable rates of touch-up injections (71% vs 66%). Safety profiles were also equivalent, confirming Lunaphil Ultra as a reliable alternative in this patient population ✅.
These findings offer actionable insight for clinicians selecting HA fillers for NLF correction and highlight the importance of evidence-based product choices in aesthetic practice.
Full article: https://doi.org/10.1093/asj/sjaf156