11/10/2025
Regenerative therapy offers a new treatment avenue for vulvar lichen sclerosus (VLS).
VLS is a chronic inflammatory condition that can significantly impact quality of life and often shows limited response to corticosteroids.
In this prospective, open-label study, 18 women (ages 24–81) with moderate-to-severe VLS received a single intra- and subdermal injection of nanofat (40 cc) and stromal vascular fraction (2–3 cc) into vulvar and perianal regions. Follow-up occurred at 1, 3, 6, and 12 months, assessing symptoms, itching, quality of life, and sexual function using validated scales.
At 12 months, patients experienced significant improvement in symptoms and signs of VLS. Itching decreased and quality of life improved. Histology confirmed reduced stromal hyalinization, decreased T-cell infiltration, and increased microvascular density. No serious adverse events were reported.
These results suggest that the Lichen-SVF protocol is a safe and effective regenerative option that complements conventional corticosteroid therapy, offering long-term symptom relief and tissue regeneration.
🔗 Read the full article in the Aesthetic Surgery Journal: https://doi.org/10.1093/asj/sjaf148