05/23/2024
SUPPLEMENTS YOU NEED TO BE TAKING: OMEGA-3
In this last of my 3-part series, let's look at Omega-3 (O3) polyunsaturated fatty acids. O3 fatty acids naturally occur in 3 forms: ALA (alpha linolenic acid), EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid). EPA and DHA are found in marine sources, primarily cold water fish and krill. ALA is found in plant sources. Although ALA can convert to EPA & DHA in the body, the conversion is VERY small, and therefore ALA is a poor source of EPA & DHA.
Omega-3s play important roles in the body. They are key components of the cell membrane. DHA, in particular, is especially high in the retina, brain, and s***m. They also provide energy for the body, and they are used to form eicosanoids. Eicosanoids are signaling molecules that have wide-ranging functions in the body’s cardiovascular, pulmonary, immune, and endocrine systems.
In particular, whereas the eicosanoids made from omega-6 fats are generally more potent mediators of inflammation, vasoconstriction, and platelet aggregation (clumping), EPA and DHA tip the eicosanoid balance toward less inflammatory activity.
A 2009 Harvard study looked at the 6 leading preventable causes of death including high blood pressure, smoking, diabetes, and consumption of trans fats. They found that insufficient levels of EPA + DHA was in the top 6! Specifically, they estimated that insufficient levels of EPA + DHA was responsible for 84,000 deaths/year. (Eating trans fats resulted in 82,000 deaths/year.)
The best way to know if you are getting enough O3's is a blood test known as the "Omega 3 Index." This test looks O3 levels in the red cell membranes, not serum. So it's a much more stable, reliable, and accurate measurement. Sadly most clinicians don't even know about the test. (One lab that performs the test is Mosaic Diagnostics, www.MosaicDx.com.)
Research has found that those with the highest O3 index (8% or greater) had a 90% reduced risk of sudden cardiac death vs those with a low index (4% or lower). Having an index of 8% or higher leads to a +5 year or life expectancy vs those with a 4% index.
O3 are so important that they can even blunt the effect of smoking. While the greatest life expectancy is seen in non-smokers with a high O3 index, smokers with a high O3 index had the same life expectancy as non-smokers with a low index!
Since most people in western cultures don't (or can't) eat enough fish to get a high O3 index, supplementation is the best source. Taking 2 grams a day of combined EPA+DHA can raise your O3 index from 4% to 8%. Look for high quality sources that are tested for PCBs, mercury, rancidity. Reputable sources include Vital Nutrients and Nordic Naturals. EPA +DHA is also available via prescription as Lovaza®. Doses of 4g/day or higher have anti-inflammatory benefits. I routinely recommend that people get 4g/day unless contraindicated.