03/01/2026
🐴 Senior Horse Sunday: Cushing’s Disease (PPID) 🐴
Cushing’s disease—also known as Pituitary Pars Intermedia Dysfunction (PPID)—is a common condition in older horses. It’s caused by a benign tumor of the pituitary gland, leading to overproduction of hormones (especially ACTH) that can affect multiple body systems.
🔍 Common Signs Owners May Notice:
• Long, curly hair coat or failure to shed
• Loss of topline or muscle
• Weight loss
• Laminitis/founder
• Increased drinking and urination
• Changes in sweating (patchy or none at all)
• Chronic or slow-healing infections (eye ulcers, hoof abscesses, rain rot)
🧪 How Is PPID Diagnosed?
• Baseline ACTH test: Most common screening tool (levels may naturally rise in fall)
• TRH Stimulation Test: More sensitive, especially for early disease
• Annual re-testing is recommended once treatment begins to ensure proper dosing
💊 Treatment Options:
• Prascend® (pergolide) is the FDA-approved treatment
• Typically given as 1 tablet daily (dose may vary by horse)
• Temporary decreased appetite may occur when starting—often resolved by gradually increasing the dose
• Less common side effects include lethargy or behavior changes
• Other medications exist but generally have lower to no effectiveness
🩺 Early diagnosis and proper management can greatly improve your senior horse’s comfort, health, and quality of life. If you notice any of these signs, please call us to discuss!
💙 Because our senior horses deserve extra care.