02/12/2026
DHEA is often marketed as an “adrenal adaptogen” that balances cortisol—but cortisol rhythms, stress physiology, and circadian regulation are more nuanced than that. This evidence-based article explores what a normal cortisol slope looks like, when a steeper decline is adaptive vs maladaptive, and how DHEA and pregnenolone differ mechanistically in clinical decision-making.
Click to read and learn what the science really says about DHEA, cortisol, and “adrenal fatigue.
DHEA, cortisol slope, and circadian regulation explained for clinical clarity.