12/06/2025
Autistic Adults & Autoimmunity: Why This Connection Deserves More Attention
I went down a rabbit hole recently—like I always do when something feels personal or sparks my curiosity, and I ended up learning about something we really don’t talk about enough: the connection between autism and autoimmune conditions.
It made me wonder… is this correlation, causation, or a mix of both?
We often talk about autism in terms of communication or sensory needs, but we don’t talk nearly enough about the body that autism lives in. Autistic people have real physical experiences, and so many of those experiences get brushed aside or misunderstood.
Research keeps showing higher rates of autoimmune issues in autistic adults—things like thyroid disorders or chronic gut inflammation. Older studies highlighted immune system differences, and newer work is digging even deeper into innate immune dysfunction and chronic neuroinflammation. It’s not definitive, but it’s a pattern worth paying attention to.
And honestly… when you understand how the body’s systems talk to each other, it makes sense. The nervous system and immune system are in constant communication. If someone has spent years in sensory overwhelm, masking, or feeling chronically unsafe in the world, that takes a toll.
Sometimes it even shows up as autoimmunity.
What really hit me is how validating this is.
Fatigue isn’t laziness.
Gut issues aren’t “just stress.”
Brain fog isn’t a lack of effort.
These are real physical signs that deserve genuine care.
And yes—nutrition plays a role too. Not as a cure (because that’s not how this works), but as one supportive piece of the puzzle. Food affects inflammation, gut integrity, and even our resilience to stress. It’s one more tool that can help people feel more at home in their own bodies.
If we want truly integrative, compassionate care for autistic adults and kids, we can’t treat this as a fringe idea. It deserves space in the conversation.
Because when people finally get answers that line up with their lived experience, they also get options—and hope—that they’ve been missing for way too long.
References
Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Curr Opin Investig Drugs. 2009;10(5):463–473.
Hughes HK, Moreno RJ, Ashwood P. Innate Immune Dysfunction and Neuroinflammation in Autism Spectrum Disorder (ASD). Focus (Am Psychiatr Publ). 2024;22(2):229–241. doi:10.1176/appi.focus.24022004