11/15/2025
Infant botulism linked to powdered infant formula
Health Advisory
Distributed through the Iowa Health Alert Network
November 14, 2025, 11:24
• A multistate outbreak of infant botulism has been linked to consuming ByHeart Whole Nutrition powdered infant formula; 15 infants across 12 states have been hospitalized and treated with immunoglobulin called BabyBIG®. No cases have been identified in Iowa.
• Iowans should stop using any ByHeart Whole Nutrition formula, including single serve packets (photos on last page). A national recall has been initiated for the formula, but it’s possible the formula is still being consumed. The WIC formula supply is not affected.
What is Infant Botulism
Infant botulism occurs when an infant ingests spores from a type of bacteria called Clostridium botulinum, which then grows in the large intestine and produces toxin that blocks the neuromuscular junction by inhibiting the release of acetylcholine. Initial signs and symptoms often include constipation, difficulty feeding (difficulty
sucking or swallowing), loss of head control, weak facial expression, and reduced muscle tone. Without prompt recognition and treatment, descending paralysis may progress and involve the respiratory muscles, potentially leading to life-threatening respiratory failure. The time from ingestion to symptom presentation can be up to 30 days.
Patient/caregiver guidance when ByHeart formula was used:
• Do not use any ByHeart Whole Nutrition infant formula. This includes formula sold in cans and single serve packets.
o If possible, take a picture or record the lot number and best by date.
o If you have leftover ByHeart powdered formula, label it "DO NOT USE" and keep it stored in a safe place for at least a month.
o If your infant develops symptoms of infant botulism, your state health department may want to collect it for testing. If no symptoms appear after a month, throw the leftover formula away.
• Monitor for symptoms of botulism such as poor feeding, loss of head control, difficulty swallowing, or decreased facial expression, seek medical care immediately if symptoms appear. Early intervention is critical.
• Wash items and surfaces that may have touched the formula using hot soapy water or a dishwasher.
For more information, contact Myrtue Public Health at 712.755.4308.