02/10/2020
In the early 2010s, scientists pivoted away from believing that the brain and body function as church and state entities, and began to embrace an entirely new brain-body paradigm that tells us that the brain is also governed by the immune system.
This ground-breaking science couldn’t come a moment too soon. As we look back over the past decade, one thing is disturbingly apparent: We are increasingly a people in despair. For many, when despair becomes depression, or untenable anxiety, the standard answers — antidepressants with a dose of therapy — are not enough to assuage suffering.
The past decade has been a golden era in brain research, one in which scientists have offered extraordinary hope for today’s mental health crisis by rewriting our basic understanding of how disorders of the human brain develop, and how we might help prevent or ameliorate them. And they all come down to one tiny, elusive cell, called microglia, which turn out to be game-changers for mental health.
Our body and brain are constantly chatting in a bidirectional conversation about whether we are safe, or not safe. When our brain gets the message we aren’t safe, this brain immune inflammatory response — led by microglia — can lead to depression, anxiety, and memory loss. In unhealthy or toxic environments, microglia can become the brain’s untimely assassins.
New brain research advances the understanding of trauma, stress and the immune system. First it was gray hair, then disrupting the microbiome and creating inflammation, now this. A fantastic brief read.New brain research advances the understanding of trauma, stress and the immune system. First it was gray hair, then disrupting the microbiome and creating inflammation, now this. A fantastic brief read.
More than a decade ago, I was diagnosed with several autoimmune diseases, one after another, including Guillain-Barré syndrome , which left me paralyzed twice while raising two young children. All told I spent six years in and out of bed and hospitals, learning, between crises, to use a cane or wal...